Morphological Correlates of Acute and Permanent Hearing Loss During Experimental Pneumococcal Meningitis
Morphological Correlates of Acute and Permanent Hearing Loss During Experimental Pneumococcal Meningitis
复制标题
实验性肺炎球菌脑膜炎期间急性和永久性听力损失的形态学相关性
作者：
M. Klein;U. Koedel;H. Pfister;S. Kastenbauer
在急性细菌性脑膜炎患者中，听力损失可能是短暂的，但通常是永久性的。脑膜炎相关性听力损失的机制尚未完全了解。因此，我们在肺炎球菌脑膜炎大鼠模型中研究了听力损失的形态学相关性。经皮脑池内注射肺炎链球菌导致剂量依赖性听力损失（通过听性脑干反应测听法测定），在急性期部分可逆。然而，严重的永久性听力损失持续到感染后2周。化脓性中耳炎伴有血迷路屏障破坏（通过耳蜗伊文思蓝外渗确定），这与急性期听力损失密切相关，但与恢复后无关。感染后2周，螺旋神经节神经元密度显著降低，并与永久性听力损失的严重程度相关。神经元丢失可以通过脑膜炎相关螺旋神经节神经元坏死而不是细胞凋亡的新发现来解释（通过形态学、TUNEL染色和免疫组织化学确定）。
In patients with acute bacterial meningitis, hearing loss can be transient but is often permanent. The mechanisms underlying meningitis‐associated hearing loss are not fully understood. Therefore, we investigated the morphological correlates of hearing loss in a rat model of pneumococcal meningitis. Transcutaneous intracisternal injection of Streptococcus pneumoniae resulted in a dose‐dependent hearing loss (determined by auditory brainstem response audiometry), which was partially reversible during the acute stage. Nevertheless, a severe permanent hearing loss persisted until 2 weeks after infection. Suppurative labyrinthitis was accompanied by blood‐labyrinth barrier disruption (determined by cochlear Evans blue extravasation), which correlated closely with hearing loss during the acute stage but not after recovery. Two weeks after infection, spiral ganglion neuronal density was markedly decreased and correlated with the severity of permanent hearing loss. Neuronal loss can be explained by the new finding of meningitis‐associated spiral ganglion neuronal necrosis rather than apop‐tosis (determined by morphology, TUNEL staining, and immunohistochemistry).
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急性细菌性脑膜原性迷路炎的人体颞骨研究。
DOI：
--
发表时间：
1996
期刊：
The American journal of otology.
影响因子：
--
作者：
Merchant,SN;Gopen,Q
通讯作者：
Gopen,Q
细胞间粘附分子 1 缺陷的婴儿小鼠模型中的血源性细菌性脑膜炎。
DOI：
10.1093/infdis/171.2.342
发表时间：
1995
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Tan,TQ;Smith,CW;Hawkins,EP;MasonJr,EO;Kaplan,SL
通讯作者：
Kaplan,SL
影响因子：
4.4
作者：
Leib, SL;Täuber, MG
通讯作者：
Täuber, MG
螺旋缘的正常和病理特征及其功能意义。
影响因子：
2.5
作者：
Kimura,RS;Nye,CL;Southard,RE
通讯作者：
Southard,RE