Correlation of neural response properties with auditory thalamus subdivisions in the awake marmoset
Correlation of neural response properties with auditory thalamus subdivisions in the awake marmoset
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DOI：
10.1152/jn.00238.2010
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发表时间：
2011-06-01
影响因子：
2.5
通讯作者：
Wang, Xiaoqin
中科院分区：
文献类型：
--
作者：
Bartlett, Edward L.;Wang, Xiaoqin
Bartlett EL，Wang X.清醒状态下绒猴神经反应特性与听觉丘脑分区的相关性。J Neurophysiol 105：2647-2667，2011.首次发表于2011年3月16日; doi：10.1152/jn.00238.2010.-作为几乎所有听觉输入到达皮层的信息瓶颈，听觉丘脑是建立听觉皮层处理流的基础。听觉丘脑的初级和非初级细分的功能组织没有得到很好的表征，特别是在清醒的灵长类动物。我们记录了清醒的绒猴听觉丘脑的神经元，并测试了它们对音调、带通噪声和时间调制刺激的反应。我们分析了记录的神经元的光谱和时间响应特性，并将这些特性与它们在听觉丘脑中的位置相关联，从而形成了并行输出通道的基础。三个内侧膝状体（MGB）的细分确定和生理和解剖学研究，虽然其他内侧细分也确定了解剖。腹侧亚部（MGV）的神经元急剧调谐的频率，首选窄带刺激，并能够同步快速的时间调制。前背亚部（MGAD）神经元似乎非常适合于时间处理，类似的音调或噪声刺激，但能够同步到最高的调制频率和最高的时间精度之间的MGB细分。后背亚部（MGPD）神经元与其他两个亚部有很大不同，许多神经元更喜欢宽带刺激和信号调制频率的变化与非同步变化的放电率。大多数神经元在所有的细分作出反应，增加音调的声音水平与非单调的变化，放电率。MGV和MGAD神经元表现出的反应与提供丘脑皮质输入的核心区域一致，而MGPD神经元与提供输入带区域一致。
Bartlett EL, Wang X. Correlation of neural response properties with auditory thalamus subdivisions in the awake marmoset. J Neurophysiol 105: 2647-2667, 2011. First published March 16, 2011; doi:10.1152/jn.00238.2010.-As the information bottleneck of nearly all auditory input that reaches the cortex, the auditory thalamus serves as the basis for establishing auditory cortical processing streams. The functional organization of the primary and nonprimary subdivisions of the auditory thalamus is not well characterized, particularly in awake primates. We have recorded from neurons in the auditory thalamus of awake marmoset monkeys and tested their responses to tones, band-pass noise, and temporally modulated stimuli. We analyzed the spectral and temporal response properties of recorded neurons and correlated those properties with their locations in the auditory thalamus, thereby forming the basis for parallel output channels. Three medial geniculate body (MGB) subdivisions were identified and studied physiologically and anatomically, although other medial subdivisions were also identified anatomically. Neurons in the ventral subdivision (MGV) were sharply tuned for frequency, preferred narrowband stimuli, and were able to synchronize to rapid temporal modulations. Anterodorsal subdivision (MGAD) neurons appeared well suited for temporal processing, responding similarly to tone or noise stimuli but able to synchronize to the highest modulation frequencies and with the highest temporal precision among MGB subdivisions. Posterodorsal subdivision (MGPD) neurons differed substantially from the other two subdivisions, with many neurons preferring broadband stimuli and signaling changes in modulation frequency with nonsynchronized changes in firing rate. Most neurons in all subdivisions responded to increases in tone sound level with nonmonotonic changes in firing rate. MGV and MGAD neurons exhibited responses consistent with provision of thalamocortical input to core regions, whereas MGPD neurons were consistent with provision of input to belt regions.