Penicillin-insensitive pneumococci. Case report and review.
Penicillin-insensitive pneumococci. Case report and review.
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对青霉素不敏感的肺炎球菌。
DOI：
10.1001/archpedi.1979.02130020079017
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发表时间：
1979
影响因子：
--
通讯作者：
M. Marks
中科院分区：
文献类型：
--
作者：
G. Ahronheim;B. Reich;M. Marks
对青霉素敏感性（或耐药性）降低的肺炎球菌引起的感染很少被发现。我们的经验和其他人的经验表明：（1）重要肺炎球菌分离株的青霉素敏感性试验应成为常规;（2）青霉素可能不足以治疗青霉素最小抑菌浓度大于0.1 μ g/ml的肺炎球菌引起的CNS感染;和（3）在这些微生物流行的地区，长期青霉素“预防”可能不适合脾切除患者。
Infections due to pneumococci with decreased susceptibility (or resistance) to penicillin have been infrequently recognized. Our experience and that of others suggest that (1) penicillin susceptibility testing of significant pneumococcal isolates should become routine; (2) penicillin may not be adequate therapy for CNS infections due to pneumococci whose penicillin minimal inhibitory concentration is greater than 0.1 microgram/ml; and (3) long-term penicillin "prophylaxis" may be inappropriate in the splenectomized patient in areas where these organisms are prevalent.