Intracerebroventricular drug administration.
Intracerebroventricular drug administration.
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DOI：
10.12793/tcp.2017.25.3.117
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发表时间：
2017-09-01
影响因子：
0.9
通讯作者：
Atkinson, Arthur J Jr
中科院分区：
文献类型：
--
作者：
Atkinson, Arthur J Jr
在各种给药途径中，研究最少的可能是脑室内给药。这一途径已被证明在给中枢神经系统(CNS)注射不易通过血脑屏障的药物时特别有用。因此，ICV途径是一个有价值的选择，可以提供治疗中枢神经系统感染和肿瘤疾病的中枢神经系统药物浓度。这种给药途径还具有将全身毒性降至最低的优势。
Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration. This route has been shown to be particularly useful in administering to the central nervous system (CNS) drugs that do not cross the blood-brain barrier readily. As such, the ICV route is a valuable option for providing therapeutic CNS drug concentrations to treat patients with CNS infectious and neoplastic diseases. This route of drug administration also has the advantage of minimizing systemic toxicity.