Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3.
Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3.
复制标题
与大鼠 3 号染色体上的 Edpm3 基因座相关的血管生成和毛细血管成熟表型。
DOI：
10.1007/s00335-005-2450-4
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Wendell,DouglasL
中科院分区：
文献类型：
--
作者：
Pandey,Jyotsna;Wendell,DouglasL
The quantitative trait locus (QTL)Edpm3is one of a group of additively acting QTL \responsible for the difference in estrogen-induced pituitary tumor growth between the tumor-susceptible F344 and tumor-resistant BN rat strains. The F344.BN-Edpm3BNrat strain was produced by moving the segment of rat Chr 3 betweenD3Mgh7andD3Mgh13, which contains theEdpm3QTL, from the BN strain into the F344 genetic background. In a previous study, we used this congenic line to find that the BN allele of theEdpm3QTL reduces tissue mass and S-phase fraction in the estrogen-induced rat pituitary tumor. We now report on the use of this congenic line to investigate the linkage ofEdpm3to tumor angiogenesis. Contrary to expectation, the F344.BN-Edpm3BNstrain has significantly greater angiogenic activity than does F344 in both treated and untreated rats. Microvessel count (MVC), perivascular space, and number of nonattached pericytes/pericapillary fibroblasts are all elevated in the pituitary by chronic estrogen treatment and their values are significantly greater in F344.BN-Edpm3BNthan F344. Thus, although there is greater angiogenic activity in the pituitary of estrogen-treated F344.BN-Edpm3BNrats, there is a deficiency in capillary maturation compared with F344.
