Postsynaptic neural activity regulates neuronal addition in the adult avian song control system.
Postsynaptic neural activity regulates neuronal addition in the adult avian song control system.
复制标题
突触后神经活动调节成年鸟类鸣叫控制系统中的神经元添加。
DOI：
10.1073/pnas.1310237110
复制
发表时间：
2013
影响因子：
11.1
通讯作者：
Brenowitz,EliotA
中科院分区：
文献类型：
--
作者：
Larson,TracyA;Wang,Tsu-Wei;Gale,SamuelD;Miller,KimberlyE;Thatra,NivrettaM;Caras,MelissaL;Perkel,DavidJ;Brenowitz,EliotA
神经系统的一个显著特征是它显示出广泛的结构和功能可塑性，使动物能够适应环境的变化。神经活动在介导经验依赖性神经可塑性方面起着关键作用，因此，在外部环境，神经系统和行为之间建立了联系。神经可塑性的一个引人注目的例子是成人大脑中正在进行的神经发生。然而，神经活动在调节神经元加法中的作用还没有在神经回路水平上得到很好的研究。鸟类的歌声控制系统使我们能够研究活动如何影响神经元的神经回路，调节歌曲，学习感觉运动的社会行为。在成年白冠麻雀中，新的神经元不断添加到鸣唱核HVC（专有名称），并将其轴突投射到其靶核，即Arcopallium（RA）的鲁棒核。我们在这里报告，RA的电活动调节神经元除了HVC。通过脑内灌注GABA A受体激动剂蝇蕈醇减少RA的神经活动，使新的HVC神经元数量减少了56%。我们的研究结果表明，突触后电活动的影响，除了新的神经元到一个功能的神经回路在成年鸟类。
A striking feature of the nervous system is that it shows extensive plasticity of structure and function that allows animals to adjust to changes in their environment. Neural activity plays a key role in mediating experience-dependent neural plasticity and, thus, creates a link between the external environment, the nervous system, and behavior. One dramatic example of neural plasticity is ongoing neurogenesis in the adult brain. The role of neural activity in modulating neuronal addition, however, has not been well studied at the level of neural circuits. The avian song control system allows us to investigate how activity influences neuronal addition to a neural circuit that regulates song, a learned sensorimotor social behavior. In adult white-crowned sparrows, new neurons are added continually to the song nucleus HVC (proper name) and project their axons to its target nucleus, the robust nucleus of the arcopallium (RA). We report here that electrical activity in RA regulates neuronal addition to HVC. Decreasing neural activity in RA by intracerebral infusion of the GABAAreceptor agonist muscimol decreased the number of new HVC neurons by 56%. Our results suggest that postsynaptic electrical activity influences the addition of new neurons into a functional neural circuit in adult birds.