PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
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DOI：
10.1038/nm1291
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发表时间：
2005-09-01
期刊：
影响因子：
82.9
通讯作者：
Carrera, AC
中科院分区：
文献类型：
--
作者：
Barber, DF;Bartolomé, A;Carrera, AC
系统性红斑狼疮（SLE）是一种由T细胞介导的B细胞活化失调引起的慢性炎症性疾病，其导致肾小球肾炎和肾衰竭。疾病的治疗与免疫抑制剂和细胞生长抑制剂，有许多副作用。在此，我们研究了在SLE的MRL- Ipr小鼠模型中磷酸肌醇3-激酶（PI 3 K）γ（一种调节炎症的脂质激酶）抑制剂的应用。治疗减少肾小球肾炎和延长寿命，表明PI 3 K γ可能是治疗慢性炎症的有用靶点。
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease generated by deregulation of T cell - mediated B- cell activation, which results in glomerulonephritis and renal failure. Disease is treated with immunosuppressants and cytostatic agents that have numerous side effects. Here we examine the use of inhibitors of phosphoinositide 3- kinase (PI3K) gamma, a lipid kinase that regulates inflammation, in the MRL- Ipr mouse model of SLE. Treatment reduced glomerulonephritis and prolonged lifespan, suggesting that PI3K gamma may be a useful target in the treatment of chronic inflammation.