Interstitial fluid flow in canaliculi as a mechanical stimulus for cancellous bone remodeling: in silico validation
Interstitial fluid flow in canaliculi as a mechanical stimulus for cancellous bone remodeling: in silico validation
复制标题
DOI：
10.1007/s10237-013-0539-3
复制
发表时间：
2014-08-01
影响因子：
3.5
通讯作者：
Adachi, Taiji
中科院分区：
文献类型：
--
作者：
Kameo, Yoshitaka;Adachi, Taiji
松质骨具有动态的小梁三维结构，其排列通过骨重建不断重组以适应机械环境。骨细胞被认为是主要的力学感觉细胞，并调节骨细胞骨吸收和成骨细胞骨形成响应于机械刺激。我们以前开发了一个数学模型的骨小梁重建纳入细胞mechanosensing和细胞间通讯的可能机制，其中我们假设，间质液流激活骨细胞调节骨重建。虽然所提出的模型已通过模拟单个骨小梁的重塑进行了验证，但尚不清楚它是否能成功地在计算机上代表具有多个骨小梁的松质骨的功能适应。在本研究中，我们证明了松质骨形态的单轴或弯曲载荷使用我们的重建模型与体素有限元方法相结合的反应。在该模拟中，具有随机排列的小梁的松质骨被重塑以形成平行于载荷方向的组织良好的结构，与先前的模拟结果和实验结果一致。这些结果表明，我们的松质骨重建的数学模型，使我们能够预测松质骨结构的重组细胞活动。此外，我们的重建模型可以代表骨转化的现象学规律，朝着一个局部均匀的状态的应力或应变在小梁水平。
Cancellous bone has a dynamic 3-dimensional architecture of trabeculae, the arrangement of which is continually reorganized via bone remodeling to adapt to the mechanical environment. Osteocytes are currently believed to be the major mechanosensory cells and to regulate osteoclastic bone resorption and osteoblastic bone formation in response to mechanical stimuli. We previously developed a mathematical model of trabecular bone remodeling incorporating the possible mechanisms of cellular mechanosensing and intercellular communication in which we assumed that interstitial fluid flow activates the osteocytes to regulate bone remodeling. While the proposed model has been validated by the simulation of remodeling of a single trabecula, it remains unclear whether it can successfully represent in silico the functional adaptation of cancellous bone with its multiple trabeculae. In the present study, we demonstrated the response of cancellous bone morphology to uniaxial or bending loads using a combination of our remodeling model with the voxel finite element method. In this simulation, cancellous bone with randomly arranged trabeculae remodeled to form a well-organized architecture oriented parallel to the direction of loading, in agreement with the previous simulation results and experimental findings. These results suggested that our mathematical model for trabecular bone remodeling enables us to predict the reorganization of cancellous bone architecture from cellular activities. Furthermore, our remodeling model can represent the phenomenological law of bone transformation toward a locally uniform state of stress or strain at the trabecular level.