Mortality among participants in the agricultural health study
Mortality among participants in the agricultural health study
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DOI：
10.1016/j.annepidem.2004.08.008
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发表时间：
2005-04-01
影响因子：
5.6
通讯作者：
Alavanja, MCR
中科院分区：
文献类型：
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作者：
Blair, A;Sandler, DP;Alavanja, MCR
目的：这项农业健康研究队列分析评估了有执照的农药施用者及其配偶的死亡经历。方法：这份报告基于爱荷华州和北卡罗来纳州农民的52,393名私人施药者(主要是农民)和32,345名农民的配偶。在注册时，每个农药施用者都完成了一份21页的注册调查问卷。从1994-1997年到2000年的死亡率评估提供了平均5.3年的随访时间，447,154人年，2055例死亡。结果：与两个州的普通人群相比，队列人群的死亡率非常低。总死亡率、心血管疾病、糖尿病、COPD、总死亡率的标准化死亡率(SMR)。对于农民和配偶来说，癌症以及食道癌、胃癌和肺癌的发病率都在0.6或更低。这些缺陷几乎不受农场规模、农场作物或牲畜类型、处理杀虫剂的年限、从事非农业工作或随访时间的影响。曾经吸烟者的SMR没有从不吸烟者低，但在所有与吸烟相关的死因中，SMR仍然低于1.0。没有发生统计上显著的过量，但在以前的研究中，与农业相关的疾病的SMR略有升高，或接近1.0。结论：几个因素可能导致了在该人群中观察到的低死亡率，包括在工作人口队列中典型的健康工作者效应(未来几年可能会下降)，较短的随访间隔，以及通过减少吸烟和传统上需要高水平体力活动的职业表现的更健康的生活方式。(C)2004 Elsevier Inc.保留所有权利。
PURPOSE: This analysis of the Agricultural Health Study cohort assesses the mortality experience of licensed pesticide applicators and their spouses.METHODS: This report is based on 52,393 private applicators (who are mostly farmers) and 32,345 spouses of farmers in Iowa and North Carolina. At enrollment, each pesticide applicator completed a 2 1 page enrollment questionnaire. Mortality assessment from enrollment (1994-1997) through 2000 provided an average follow-up of about 5.3 years, 447,154 person-years, and 2055 deaths.RESULTS: Compared with the general population in the two states, the cohort experienced a very low mortality rate. Standardized mortality ratios (SMRs) for total mortality, cardiovascular disease, diabetes, COPD, total. cancer, and cancers of the esophagus, stomach, and lung were 0.6 or lower for both farmers and spouses. These deficits varied little by farm size, type of crops or livestock on the farm, years of handling pesticides, holding a non-farm job, or length of follow up. SMRs among ever smokers were not as low as among never smokers, but were still less than 1.0 for all smoking-related causes of death. No statistically significant excesses occurred, but slightly elevated SMRs, or those near 1.0, were noted for diseases that have been associated with farming in previous studies.CONCLUSIONS: Several factors may contribute to the low mortality observed in this population, including the healthy worker effect typically seen in cohorts of working populations (which may decline in future years), a short follow-up interval, and a healthier lifestyle manifested through lower cigarette use and an occupation that has traditionally required high levels of physical activity. (c) 2004 Elsevier Inc. All rights reserved.