Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors
Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors
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DOI：
10.1016/j.jinf.2016.08.021
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发表时间：
2017-01-01
影响因子：
28.2
通讯作者：
Babu, Subash
中科院分区：
文献类型：
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作者：
Kumar, Nathella Pavan;Moideen, Kadar;Babu, Subash
背景：肺结核-糖尿病共病(TB-DM)的特征是炎症增加，循环中炎性细胞因子和其他因素水平升高。方法：检测44例TB-DM患者和44例单纯TB患者外周血中血管生成因子的表达水平，以探讨血管生成因子与TB-DM的关系。结果：TB-DM患者外周血中的VEGF-A、C、D、R1、R2、R3水平均显著高于TB-DM患者。此外，伴有双侧或空洞性病变或咯血的TB-DM患者血清中的血管内皮生长因子-A、C、R2和/或R3水平显著升高，提示其与疾病严重程度和不良临床表现有关。这些因素的水平也与细菌负荷和HbA1c水平呈显著正相关。此外，培养阳性患者的VEGFA、C和R2水平(治疗2个月时)显著高于培养阴性的TB-DM患者。化疗成功6个月后，循环血管内皮生长因子A、C、D、R1、R2和R3水平显著降低。结论：TB-DM与循环血管生成因子水平升高有关，可能反映了血管生成失调和炎症反应过度。由爱思唯尔有限公司代表英国感染协会出版。
Background: Tuberculosis-diabetes co-morbidity (TB-DM) is characterized by increased inflammation with elevated circulating levels of inflammatory cytokines and other factors. Circulating angiogenic factors are intricately involved in the angiogenesis-inflammation nexus.Methods: To study the association of angiogenic factors with TB-DM, we examined the systemic levels of VEGF-A, VEGF-C, VEGF-D, VEGF-R1, VEGF-R2, VEGF-R3 in individuals with either TB-DM ( n = 44) or TB alone ( n = 44).Results: Circulating levels of VEGF-A, C, D, R1, R2 and R3 were significantly higher in TB-DM compared to TB individuals. Moreover, the levels of VEGF-A, C, R2 and/or R3 were significantly higher in TB-DM with bilateral or cavitary disease or with hemoptysis, suggesting an association with both disease severity and adverse clinical presentation. The levels of these factors also exhibited a significant positive relationship with bacterial burdens and HbA1c levels. In addition, VEGFA, C and R2 levelswere significantly higher (at 2 months of treatment) in culture positive compared to culture negative TB-DM individuals. Finally, the circulating levels of VEGF-A, C, D, R1, R2 and R3 were significantly reduced following successful chemotherapy at 6 months.Conclusion: Our data demonstrate that TB-DM is associated with heightened levels of circulating angiogenic factors, possibly reflecting both dysregulated angiogenesis and exaggerated inflammation. Published by Elsevier Ltd on behalf of The British Infection Association.