A mathematical model for cell cycle-specific cancer virotherapy
A mathematical model for cell cycle-specific cancer virotherapy
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DOI：
10.1080/17513758.2011.613486
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Wares, Joanna R.
中科院分区：
文献类型：
--
作者：
Crivelli, Joseph J.;Foeldes, Juraj;Wares, Joanna R.
溶瘤病毒优先感染癌细胞并在癌细胞中复制，从而消除肿瘤群体，同时保留大多数健康细胞。在这里，我们研究病毒的细胞周期特异性活性，如水泡性口炎病毒（VSV）。尽管VSV具有强大的细胞溶解剂的能力，但在细胞周期的静止期或静息期，VSV不能有效地攻击某些肿瘤细胞类型。为了了解细胞周期的时间进程和VSV的特异性之间的相互作用，我们开发了一个周期特异性病毒治疗的数学模型。我们将最小的生物学所需的时间花费在非静止细胞周期阶段使用微分方程系统与合并的时间延迟。通过对模型的分析和模拟，我们描述了如何改变最小循环时间和控制病毒动力学的参数，影响无癌平衡的稳定性，这代表了治疗的成功。
Oncolytic viruses preferentially infect and replicate in cancerous cells, leading to elimination of tumour populations, while sparing most healthy cells. Here, we study the cell cycle-specific activity of viruses such as vesicular stomatitis virus (VSV). In spite of its capacity as a robust cytolytic agent, VSV cannot effectively attack certain tumour cell types during the quiescent, or resting, phase of the cell cycle. In an effort to understand the interplay between the time course of the cell cycle and the specificity of VSV, we develop a mathematical model for cycle-specific virus therapeutics. We incorporate the minimum biologically required time spent in the non-quiescent cell cycle phases using systems of differential equations with incorporated time delays. Through analysis and simulation of the model, we describe how varying the minimum cycling time and the parameters that govern viral dynamics affect the stability of the cancer-free equilibrium, which represents therapeutic success.