Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like cell populations
Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like cell populations
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DOI：
10.1634/stemcells.2006-0504
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发表时间：
2007-07-01
期刊：
影响因子：
5.2
通讯作者：
Nakamura, Yukio
中科院分区：
文献类型：
--
作者：
Sudo, Kazuhiro;Kanno, Megunh;Nakamura, Yukio
间充质祖细胞（MSCs）和间充质祖细胞（mesenchal progenitor cells, MPCs）在再生医学中的应用潜力备受关注。特别是间充质干细胞具有巨大的潜力，因为各种报告表明它们可以分化成许多不同的细胞类型。然而，间充质干细胞/祖细胞和所谓的成纤维细胞之间的区别尚不清楚。在这项研究中，我们发现大多数不同的原代成纤维细胞样细胞来源于各种人体组织，包括肺、皮肤、脐带和羊膜，包含能够分化成至少一种间充质谱系的细胞，包括成骨细胞、软骨细胞和脂肪细胞。因此，我们提出，从各种人体组织中获得的原代成纤维细胞样细胞群并不仅仅包括成纤维细胞，而是在某种程度上至少包括MPCs和可能的MSCs。
MSCs and mesenchymal progenitor cells (MPCs) are studied for their potential in regenerative medicine. MSCs in particular have great potential, because various reports have shown that they can differentiate into many different cell types. However, the difference between mesenchymal stem/progenitor cells and so-called fibroblasts is unclear. In this study, we found that most of the distinct populations of primary fibroblast-like cells derived from various human tissues, including lung, skin, umbilical cord, and amniotic membrane, contained cells that were able to differentiate into at least one mesenchymal lineage, including osteoblasts, chondrocytes, and adipocytes. We therefore propose that primary fibroblast-like cell populations obtained from various human tissues do not comprise solely fibroblasts, but rather that they also include at least MPCs and possibly MSCs, to some extent.