Effects of endurance training on the circadian rhythm of fibrinolysis in men and women.
Effects of endurance training on the circadian rhythm of fibrinolysis in men and women.
复制标题
耐力训练对男性和女性纤溶昼夜节律的影响。
DOI：
10.1097/00005768-199606000-00001
复制
发表时间：
1996
影响因子：
4.1
通讯作者：
Vitiello,MV
中科院分区：
文献类型：
--
作者：
Chandler,WL;Schwartz,RS;Stratton,JR;Vitiello,MV
这项随机研究比较了健康老年男性和老年女性（平均年龄66+/-5岁）在耐力训练前后6个月与拉伸对照组的纤溶昼夜节律。与男性相比，基线时女性的组织纤溶酶原激活物（t-PA）活性和纤溶酶原激活物抑制剂1 （PAI-1）活性节律相似，但总t-PA抗原水平较低。在男性（N= 16）中，耐力训练使VO2max增加了15%(P< 0.001)，而在午夜至早上6点之间，PAI-1活性降低了37%(P= 0.034)，总t-PA抗原降低了18%(P= 0.0003)，但对t-PA活性没有影响。在女性（N= 9）中，在晚上10点至凌晨4点之间，耐力训练使VO2max增加18%(P= 0.003)， t-PA活性增加20%(P= 0.027)， t-PA总抗原增加55%(P= 0.007)，但对PAI-1活性没有影响。耐力训练后，男性和女性的纤溶昼夜节律没有显著差异。6个月的非有氧拉伸对男性（N= 11）和女性（N= 8）的最大摄氧量和纤维蛋白溶解没有影响。这项研究表明，老年男性和老年女性在耐力训练后，纤维蛋白溶解因子发生了潜在的有利变化。
This randomized study compared the fibrinolytic circadian rhythm of healthy older men and older women (average age 66+/-5), before and after 6 months of endurance training versus stretching controls. Compared with men, women at baseline had similar rhythms for tissue plasminogen activator (t-PA) activity and plasminogen activator inhibitor 1 (PAI-1) activity, but lower levels of total t-PA antigen. In men (N= 16), endurance training increased VO2max 15%(P< 0.001), while decreasing PAI-1 activity 37%(P= 0.034) and total t-PA antigen 18%(P= 0.0003) between midnight and 6 am, but did not affect t-PA activity. In women (N= 9), endurance training increased VO2max 18%(P= 0.003), and increased t-PA activity 20%(P= 0.027) and total t-PA antigen 55%(P= 0.007) between 10 pm and 4 am, but had no effect on PAI-1 activity. After endurance training there were no significant differences in the fibrinolytic circadian rhythm of men versus women. Six months of nonaerobic stretching had no effect on VO2max or fibrinolysis in men (N= 11) or women (N= 8). This study indicates that potentially favorable changes occur in fibrinolytic factors after endurance training in older men and older women.