Fatty acid composition of serum and adipose tissue lipids in males with chronic renal failure. Relations to serum lipoproteins and clinical factors.
Fatty acid composition of serum and adipose tissue lipids in males with chronic renal failure. Relations to serum lipoproteins and clinical factors.
复制标题
慢性肾功能衰竭男性血清和脂肪组织脂质的脂肪酸组成。
作者：
H. E. Norbeck;G. Walldius
我们分析了72例男性慢性肾功能衰竭（CRF）患者血清胆固醇酯（CE）、磷脂（PL）、甘油三酯（TG）和脂肪组织（AT）脂质的脂肪酸组成。16例患者接受低蛋白饮食治疗。16例血液透析。这些结果与疾病的临床方面以及血清脂质和脂蛋白浓度的异常有关。主要发现是与对照组以及未治疗和透析患者相比，饮食治疗组所有脂质中油酸的相对含量较高，亚油酸的相对含量较低。在未经治疗的受试者中也观察到相同方向的趋势，CE中的油酸和亚油酸以及PL中的油酸具有显著性。这些变化与血清脂蛋白脂质或未接受饮食或透析的患者的血清肌酐浓度无关，表明其他因素在改变CRF中的脂肪酸代谢方面更为重要。低蛋白饮食的组成，富含脂肪但亚油酸相对于油酸较低，可能是解释我们在饮食治疗组中发现的主要因素。由于血浆和AT脂质中低水平的亚油酸已被认为是动脉粥样硬化的危险因素，因此应更多地关注膳食脂肪的含量和组成，以防止这种低水平的发生。
We have analysed the fatty acid composition of serum cholesterol esters (CE), phospholipids (PL) and triglycerides (TG) and of adipose tissue (AT) lipids in 72 males and chronic renal failure (CRF). Sixteen patients were treated with protein-poor diet. 16 with hemodialysis. The results have been related to clinical aspects of the disease and to abnormalities in serum lipid and lipoprotein concentrations. The major findings were high relative content of oleic acid and a low relative content of linoleic acid in all lipids in the diet-treated group compared to both controls and to the untreated and dialysed patients. Tendencies in the same directions were seen also in the untreated subjects, significant for oleic and linoleic acid in CE and for oleic acid in PL. These changes did not correlate to serum of lipoprotein lipids, or to serum creatinine concentrations in patients not on diet or dialysis, indicating that other factors are more important in modifying the fatty acid metabolism in CRF. The composition of the protein-poor diet, which was rich in fat but low in linoleic acid in relation to oleic acid, is probably a major factor explaining our findings in the diet-treated group. Since low levels of linoleic acid in plasma and AT lipids have been suggested to be a risk factor for atherosclerosis, more attention should be paid to the content and composition of dietary fat in order to prevent the occurrence of such low levels.