A prototype model for evaluating psychiatric research strategies: Diagnostic category-based approaches vs. the RDoC approach
A prototype model for evaluating psychiatric research strategies: Diagnostic category-based approaches vs. the RDoC approach
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发表时间：
2016-09
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通讯作者：
K. Katahira;Yuichi Yamashita
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作者：
K. Katahira;Yuichi Yamashita
在本文中，我们提出了一个评估精神病学研究策略的理论框架。要评估的策略包括一个传统的诊断分类为基础的方法和维度的方法，已被鼓励由国家精神卫生研究所（NIMH），概述为研究领域标准（RDoC）。所提出的框架是基于统计建模的过程中，致病因素被翻译为行为的措施，以及如何的研究策略可以检测到潜在的致病因素。该框架提供了统计能力，用于量化在各种条件下检测相关致病因素的效率。我们提出了一些理论和数值结果突出的优点和缺点的战略。
In this paper, we propose a theoretical framework for evaluating psychiatric research strategies. The strategies to be evaluated include a conventional diagnostic category-based approach and dimensional approach that have been encouraged by the National Institute for Mental Health (NIMH), outlined as Research Domain Criteria (RDoC). The proposed framework is based on the statistical modeling of the processes by which pathogenetic factors are translated to behavioral measures and how the research strategies can detect potential pathogenetic factors. The framework provides the statistical power for quantifying how efficiently relevant pathogenetic factors are detected under various conditions. We present several theoretical and numerical results highlighting the merits and demerits of the strategies.