The Minichromosome Maintenance Replicative Helicase
The Minichromosome Maintenance Replicative Helicase
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DOI：
10.1101/cshperspect.a012807
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发表时间：
2013-11-01
影响因子：
7.2
通讯作者：
Botchan, Michael R.
中科院分区：
文献类型：
--
作者：
Bell, Stephen D.;Botchan, Michael R.
真核复制型解旋酶，微小染色体维持(MCM)复合体，由六个不同但相关的亚基MCM(2-7)组成。亚基序列之间的关系表明，它们来自共同的祖先，实际上，今天的古菌拥有一个同源六角体MCM。在真核生物和古生代MCM复合体的生化和结构研究方面的最新进展开始阐明复制体的这一关键组成部分的作用机制。
The eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex, is composed of six distinct, but related, subunits MCM(2-7). The relationship between the sequences of the subunits indicates that they are derived from a common ancestor and indeed, present-day archaea possess a homohexameric MCM. Recent progress in the biochemical and structural studies of both eukaryal and archaeal MCM complexes are beginning to shed light on the mechanisms of action of this key component of the replisome.