Nanoparticle-Coated Microbubbles for Combined Ultrasound Imaging and Drug Delivery
Nanoparticle-Coated Microbubbles for Combined Ultrasound Imaging and Drug Delivery
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DOI：
10.1021/acs.langmuir.8b04008
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发表时间：
2019-08-06
期刊：
影响因子：
3.9
通讯作者：
Garbin, Valeria
中科院分区：
文献类型：
--
作者：
Jamburidze, Akaki;Huerre, Axel;Garbin, Valeria
由磁性或含药物纳米颗粒涂层稳定的生物医学微泡在治疗诊断学应用中显示出巨大的潜力。纳米颗粒涂层的微泡可以变得稳定、产生回声，并通过超声波触发释放含有药物的纳米颗粒。本文回顾了用于超声成像和药物输送的纳米颗粒涂层微泡的设计原理，特别关注纳米颗粒涂层界面的物理化学；纳米颗粒涂层气泡的形成、稳定性和动力学；以及超声波中受控纳米颗粒释放的条件。对纳米颗粒排出模式和通过微泡诱导流输送排出物质的新认识正在为更有效的纳米颗粒介导的药物输送铺平道路。本文强调了在我们控制这些现象之前仍有待解决的知识差距。
Biomedical microbubbles stabilized by a coating of magnetic or drug-containing nanoparticles show great potential for theranostics applications. Nanoparticle-coated microbubbles can be made to be stable, to be echogenic, and to release the cargo of drug-containing nanoparticles with an ultrasound trigger. This Article reviews the design principles of nanoparticle-coated microbubbles for ultrasound imaging and drug delivery, with a particular focus on the physical chemistry of nanoparticle-coated interfaces; the formation, stability, and dynamics of nanoparticle-coated bubbles; and the conditions for controlled nanoparticle release in ultrasound. The emerging understanding of the modes of nanoparticle expulsion and of the transport of expelled material by microbubble-induced flow is paving the way toward more efficient nanoparticle-mediated drug delivery. This Article highlights the knowledge gap that still remains to be addressed before we can control these phenomena.