Vaccination by non-parenteral routes: characteristics of immune response.
Vaccination by non-parenteral routes: characteristics of immune response.
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非胃肠道途径疫苗接种：免疫反应的特征。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
A. Morag
中科院分区：
文献类型：
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作者：
P. Ogra;Y. Chiba;K. Beutner;A. Morag
研究了风疹和腮腺炎病毒自然感染或疫苗诱导感染后全身和外粘膜部位的抗体和细胞介导的免疫应答。自然风疹感染或接种RA 27/3风疹疫苗经鼻内和经常通过皮下途径导致在血清和呼吸道中定期出现抗体应答，以及循环淋巴细胞和扁桃体淋巴组织中的细胞免疫。用HPV-77和Cendehill风疹疫苗皮下免疫导致血清中的抗体应答，呼吸道中很少或没有应答。在这种免疫后，在全身或呼吸道淋巴组织中观察到最小的细胞介导的免疫应答。鼻内接种HPV-77经常引起呼吸道中的瞬时抗体和细胞介导的活性，而在血清和外周淋巴细胞中没有反应。对自然腮腺炎感染或腮腺炎减毒活疫苗皮下免疫进行的研究表明，任何一种感染途径都可能导致全身部位和呼吸道产生抗体和细胞介导的免疫应答。这些观察结果表明，通过非胃肠外途径免疫接种的免疫学结果可能取决于所用病毒抗原的类型、局部可用免疫活性组织的性质、粘膜部位捕获抗原或接受活病毒疫苗复制的能力以及相同抗原的既往致敏程度。
Antibody and cell-mediated immune response in systemic and external mucosal sites was studied after natural or vaccine induced infections with rubella and mumps viruses. Natural rubella infection or immunization with RA27/3 rubella vaccine by intranasal and frequently by the subcutaneous route resulted in regular appearance of antibody response in the serum and respiratory tract and cellular immunity in circulating lymphocytes and tonsillar lymphoid tissue. Subcutaneous immunization with HPV-77 and Cendehill rubella vaccine resulted in antibody response in the serum with little or no response in the respiratory tract. A minimal cell-mediated immune response in systemic or respiratory lymphoid tissue was observed after such immunization. Intranasal immunization with HPV-77 frequently elicited a transient antibody and cell-mediated activity in the respiratory tract with no response in the serum and peripheral lymphocytes. Studies carried out with natural mumps infection or subcutaneous immunization with live attenuated mumps vaccine suggested that either route of infection may result in the development of antibody and cell-mediated immune responses in systemic sites as well as in the respiratory tract. These observations suggest that the immunologic outcome of immunization by non-parenteral route may be determined by the types of viral antigen employed, the nature of locally available immuno-competent tissue, the ability of mucosal site to capture an antigen or accept replication of live virus vaccines, and the degree of prior sensitization with the same antigen.