Clinical Spectrum of Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Protection From Symptomatic Reinfection.
Clinical Spectrum of Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Protection From Symptomatic Reinfection.
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DOI：
10.1093/cid/ciab717
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发表时间：
2022-08-24
期刊：
影响因子：
--
通讯作者：
Gordon A
中科院分区：
文献类型：
--
作者：
Maier HE;Kuan G;Saborio S;Carrillo FAB;Plazaola M;Barilla C;Sanchez N;Lopez R;Smith M;Kubale J;Ojeda S;Zuniga-Moya JC;Carlson B;Lopez B;Gajewski AM;Chowdhury M;Harris E;Balmaseda A;Gordon A
关于社区或非临床环境中严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染在整个生命周期中引起的全谱疾病的数据很少。我们从 2020 年 3 月到 2021 年 3 月对尼加拉瓜马那瓜的 2338 名年龄 <94 岁的人进行了跟踪。通过实时逆转录聚合酶链反应 (RT-PCR) 或酶联免疫吸附测定来鉴定 SARS-CoV-2 感染。在感染时评估疾病表现或在采血时通过调查回顾性评估。 2020 年 3 月至 8 月期间出现了一次大规模疫情高峰。总共检测到 129 例 RT-PCR 阳性感染，总发病率为每 100 人年 5.3 例感染（95% 置信区间 [CI]，4.4-6.3）。血清阳性率为 56.7%（95% CI，53.5%–60.1%），从 11 岁到成年期保持一致，但 ≤ 10 岁儿童的血清阳性率较低。总体而言，31.0% 的感染有症状，其中 54.7% 为轻度感染，41.6% 为中度感染，3.7% 为重度感染。有 2 例死亡可能是由于 SARS-CoV-2 感染，感染死亡率为 0.2%。抗体滴度随年龄呈现 J 形曲线，在年龄较大的儿童和年轻人中观察到滴度最低，在老年人中滴度最高。与 SARS-CoV-2 血清阴性个体相比，年中样本中 SARS-CoV-2 血清阳性与 93.6% 的症状再感染保护率相关（95% CI，51.1%–99.2%）。该人群表现出非常高的 SARS-CoV-2 血清阳性率，且严重程度低于预期，并且对自然感染的免疫力可以防止有症状的再感染。尼加拉瓜马那瓜的一个社区队列的严重急性呼吸综合征冠状病毒 2 血清阳性率非常高，但严重程度低于预期。总体而言，69% 的感染是无症状或亚临床的，1.1% 的感染是严重的。截至 2021 年 3 月，血清阳性与有症状的再感染率高达 93.6%。
There are few data on the full spectrum of disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across the lifespan from community-based or nonclinical settings. We followed 2338 people in Managua, Nicaragua, aged <94 years from March 2020 through March 2021. SARS-CoV-2 infection was identified through real-time reverse transcription polymerase chain reaction (RT-PCR) or through enzyme-linked immunosorbent assay. Disease presentation was assessed at the time of infection or retrospectively by survey at the time of blood collection. There was a large epidemic that peaked between March and August 2020. In total, 129 RT-PCR–positive infections were detected, for an overall incidence rate of 5.3 infections per 100 person-years (95% confidence interval [CI], 4.4–6.3). Seroprevalence was 56.7% (95% CI, 53.5%–60.1%) and was consistent from age 11 through adulthood but was lower in children aged ≤10 years. Overall, 31.0% of the infections were symptomatic, with 54.7% mild, 41.6% moderate, and 3.7% severe. There were 2 deaths that were likely due to SARS-CoV-2 infection, yielding an infection fatality rate of 0.2%. Antibody titers exhibited a J-shaped curve with respect to age, with the lowest titers observed among older children and young adults and the highest among older adults. When compared to SARS-CoV-2–seronegative individuals, SARS-CoV-2 seropositivity at the midyear sample was associated with 93.6% protection from symptomatic reinfection (95% CI, 51.1%–99.2%). This population exhibited a very high SARS-CoV-2 seropositivity with lower-than-expected severity, and immunity from natural infection was protective against symptomatic reinfection. A community-based cohort in Managua, Nicaragua, had very high severe acute respiratory syndrome coronavirus 2 seropositivity but lower-than-expected severity. Overall, 69% of infections were asymptomatic or subclinical and 1.1% of infections were severe. Seropositivity was associated with 93.6% protection from symptomatic reinfection through March 2021.
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影响因子：
2.9
作者：
Leal FE;Mendes-Correa MC;Buss LF;Costa SF;Bizario JCS;de Souza SRP;Thomaz O;Tozetto-Mendoza TR;Villas-Boas LS;de Oliveira-da Silva LC;Grespan RMZ;Capuani L;Buccheri R;Domingues H;Alexander N;Mayaud P;Sabino EC
通讯作者：
Sabino EC
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
DOI：
10.1056/nejmoa2034545
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lumley SF;O'Donnell D;Stoesser NE;Matthews PC;Howarth A;Hatch SB;Marsden BD;Cox S;James T;Warren F;Peck LJ;Ritter TG;de Toledo Z;Warren L;Axten D;Cornall RJ;Jones EY;Stuart DI;Screaton G;Ebner D;Hoosdally S;Chand M;Crook DW;O'Donnell AM;Conlon CP;Pouwels KB;Walker AS;Peto TEA;Hopkins S;Walker TM;Jeffery K;Eyre DW;Oxford University Hospitals Staff Testing Group
通讯作者：
Oxford University Hospitals Staff Testing Group
影响因子：
168.9
作者：
Pollan, Marina;Perez-Gomez, Beatriz;Yotti, Raquel
通讯作者：
Yotti, Raquel
影响因子：
13.8
作者：
Logue JK;Franko NM;McCulloch DJ;McDonald D;Magedson A;Wolf CR;Chu HY
通讯作者：
Chu HY