Long-term pancreatic endocrine function following pancreatoduodenectomy with pancreaticogastrostomy
Long-term pancreatic endocrine function following pancreatoduodenectomy with pancreaticogastrostomy
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DOI：
10.1002/jso.21004
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发表时间：
2008-05-01
影响因子：
2.5
通讯作者：
Sueda, Taijiro
中科院分区：
文献类型：
--
作者：
Murakami, Yoshiaki;Uemura, Kenichiro;Sueda, Taijiro
背景和目的：本研究的目的是评估胰十二指肠切除术合并胰胃造口术后的长期胰腺内分泌功能。方法：回顾性分析52例胰十二指肠切除术合并胰胃造口术后存活3年及以上患者的资料。术前和术后3- 6个月测量血清HbA（1c）水平。结果：42例术前血清HbA（1c）水平正常的患者中有3例（5.8%）出现糖耐量恶化。这8例患者中有5例术后出现胰瘘。然而，术前血清HbA（1c）水平正常的患者的平均血清HbA（1c）水平在手术后3-10年内保持在正常范围内。结论：胰十二指肠切除术合并胰胃造口术后胰腺内分泌功能可长期维持。糖耐量受损似乎与术后胰瘘形成有关。
Background and Objectives: The aim of this study was to evaluate long-term pancreatic endocrine function following pancreatoduodenectomy with pancreaticogastrostomy.Methods: Records of 52 patients who had survived for three or more years following pancreatoduodenectomy with pancreaticogastrostomy were studied retrospectively. Serum HbA(1c) levels had been measured prior to and at 3- to 6-month intervals after surgery.Results: Three of 42 patients with normal preoperative serum HbA(1c) levels (5.8%) showed deterioration of glucose tolerance. Five of these eight patients developed a pancreatic fistula postoperatively. However, the average serum HbA(1c) levels of patients with normal preoperative serum HbA(1c) levels have remained within the normal range for 3-10 years after surgery.Conclusions: Pancreatic endocrine function was maintained for a long-term period after pancreatoduodenectomy with pancreaticogastrostomy. Impaired glucose tolerance appeared to be associated with postoperative pancreatic fistula formation.