Tenascin C protects aorta from acute dissection in mice.
Tenascin C protects aorta from acute dissection in mice.
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DOI：
10.1038/srep04051
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发表时间：
2014-02-11
影响因子：
4.6
通讯作者：
Aoki H
中科院分区：
文献类型：
--
作者：
Kimura T;Shiraishi K;Furusho A;Ito S;Hirakata S;Nishida N;Yoshimura K;Imanaka-Yoshida K;Yoshida T;Ikeda Y;Miyamoto T;Ueno T;Hamano K;Hiroe M;Aonuma K;Matsuzaki M;Imaizumi T;Aoki H
急性主动脉夹层（AAD）是由主动脉壁内膜中层破裂引起的，可立即危及生命。尽管近年来的研究表明促炎反应在AAD发病机制中的重要性，但抑制破坏性炎症反应的机制尚不清楚。在这里，我们报告，诱导tenascin-C（TNC）是一种应激诱发的保护机制，对急性血流动力学和体液应激的主动脉。腹主动脉周围应用CaCl 2导致腹主动脉硬化，这增强了血管紧张素II输注在肾上腺主动脉中的血流动力学应激和TNC诱导。Tnc基因的缺失使小鼠在主动脉应激时容易发生AAD，这伴随着TGFβ信号转导受损、细胞外基质蛋白诱导不足和过度的促炎反应。因此，TNC作为一种应力诱发的分子阻尼器，在急性应力下维持主动脉的完整性。
Acute aortic dissection (AAD) is caused by the disruption of intimomedial layer of the aortic walls, which is immediately life-threatening. Although recent studies indicate the importance of proinflammatory response in pathogenesis of AAD, the mechanism to keep the destructive inflammatory response in check is unknown. Here, we report that induction of tenascin-C (TNC) is a stress-evoked protective mechanism against the acute hemodynamic and humoral stress in aorta. Periaortic application of CaCl2 caused stiffening of abdominal aorta, which augmented the hemodynamic stress and TNC induction in suprarenal aorta by angiotensin II infusion. Deletion of Tnc gene rendered mice susceptible to AAD development upon the aortic stress, which was accompanied by impaired TGFβ signaling, insufficient induction of extracellular matrix proteins and exaggerated proinflammatory response. Thus, TNC works as a stress-evoked molecular damper to maintain the aortic integrity under the acute stress.
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影响因子：
82.9
作者：
Yoshimura, K;Aoki, H;Matsuzaki, M
通讯作者：
Matsuzaki, M
影响因子：
15.9
作者：
Longo, GM;Xiong, WF;Baxter, BT
通讯作者：
Baxter, BT
影响因子：
37.8
作者：
Van Kien, PK;Mathieu, F;Jeunemaitre, X
通讯作者：
Jeunemaitre, X
影响因子：
14.8
作者：
Huang, Da Wei;Sherman, Brad T.;Lempicki, Richard A.
通讯作者：
Lempicki, Richard A.
影响因子：
20.1
作者：
Shen YH;Zhang L;Ren P;Nguyen MT;Zou S;Wu D;Wang XL;Coselli JS;LeMaire SA
通讯作者：
LeMaire SA