MEASLES AND OTHER VIRUS-SPECIFIC IMMUNOGLOBULINS IN MULTIPLE-SCLEROSIS
MEASLES AND OTHER VIRUS-SPECIFIC IMMUNOGLOBULINS IN MULTIPLE-SCLEROSIS
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DOI：
10.1136/bmj.3.5881.612
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发表时间：
1973-01-01
影响因子：
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通讯作者：
MILLAR, JHD
中科院分区：
文献类型：
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作者：
HAIRE, M;FRASER, KB;MILLAR, JHD
通过荧光抗体法测定血清和脑脊液（CSF）中对膳食、单纯疱疹和风疹病毒具有特异性的免疫球蛋白M和G同时从30名多发性硬化症患者、30名其他神经系统疾病患者和30名“正常”对照受试者中获得。30例多发性硬化症患者中有11例血清中有IgM，与麻疹病毒感染细胞特异性反应，而30例其他神经系统疾病患者中有2例，30例正常对照中没有。用此法在脑脊液中未检测到麻疹病毒特异性IgM，血清中麻疹病毒特异性IgG的几何平均滴度在多发性硬化组明显高于对照组，而在脑脊液中检测到三种病毒的特异性IgG，表明通过血脑屏障的转移，麻疹IgG占优势。
Immunoglobulins M and G specific for meales, herpes simplex, and rubella viruses were assayed by the fluorescent antibody method in sera and cerebrospinal fluids (C.S.F.) obtained simultaneously from 30 patients with multiple sclerosis, 30 patients with other neurological diseases, and 30 “normal” control subjects. Sera of 11 out of 30 patients with multiple sclerosis had IgM which reacted specifically with measles virus-infected cells, compared with 2 out of 30 of the patients with other neurological diseases and none of the 30 normal controls. Virus-specific IgM was not found in C.S.F. by this method.The geometric mean titre of measles virus-specific IgG in serum was significantly higher in the multiple sclerosis group than in either control group, and while IgG specific for all three viruses was found in C.S.F., suggesting transfer across the blood-brain barrier, measles IgG predominated.