Association of Alcohol Intake with the Risk of Malignant Lymphoma and Plasma Cell Myeloma in Japanese: A Population-Based Cohort Study (Japan Public Health Center-based Prospective Study)
Association of Alcohol Intake with the Risk of Malignant Lymphoma and Plasma Cell Myeloma in Japanese: A Population-Based Cohort Study (Japan Public Health Center-based Prospective Study)
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DOI：
10.1158/1055-9965.epi-09-1088
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发表时间：
2010-02-01
影响因子：
3.8
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Kanda, Junya;Matsuo, Keitaro;Tsugane, Shoichiro
在亚洲人群中，很少有研究评估酒精摄入量与淋巴样肿瘤恶性淋巴瘤（ML）和浆细胞骨髓瘤（PCM）风险之间的关系。我们对95,520名日本受试者（45,453名男性和50067名女性，基线年龄为40-69岁）进行了一项大规模人群队列研究，平均随访13年，期间共发现257例ML和89例PCM。使用校正潜在混杂因素的Cox回归模型估计风险比和95%置信区间。与偶尔饮酒频率为300 g/周的NHL患者相比，每周饮酒>= 300 g/周的患者发生淋巴样肿瘤的风险显著降低（风险比为0.60；95%可信区间为0.37-0.98），这可能是由于每一类的受试者人数较少。总之，我们发现在日本人群中，酒精与淋巴样肿瘤的风险呈负相关，尤其是NHL的风险。癌症流行病学生物标志物；19 (2);429 - 34。(c) 2010年AACR。
Few studies have evaluated the association between alcohol intake and the risk of the lymphoid neoplasms malignant lymphoma (ML) and plasma cell myeloma (PCM) among Asian populations. We conducted a large-scale population-based cohort study of 95,520 Japanese subjects (45,453 men and 50,067 women; age 40-69 years at baseline) with an average 13 years of follow-up, during which a total of 257 cases of ML and 89 of PCM were identified. Hazard ratios and 95% confidence intervals were estimated using a Cox regression model adjusted for potential confounders. Alcohol intake of >= 300 g/week was associated with a significantly lower risk of lymphoid neoplasms (hazard ratio, 0.60; 95% confidence interval, 0.37-0.98) than occasional drinking at a frequency of = 300 g/week in NHL patients, probably due to the small number of subjects in each category. In conclusion, we found that alcohol had an inverse association with the risk of lymphoid neoplasms, particularly the risk of NHL, among a Japanese population. Cancer Epidemiol Biomarkers Prev; 19(2); 429-34. (c) 2010 AACR.