Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis
Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis
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DOI：
10.1034/j.1399-6576.2001.045003390.x
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发表时间：
2001-03-01
影响因子：
2.1
通讯作者：
Hammarlund-Udenaes, M
中科院分区：
文献类型：
--
作者：
Bouw, R;Ederoth, P;Hammarlund-Udenaes, M
利用脑内微透析来获取有关吗啡如何穿过血脑屏障（BBB）的信息。在一名严重脑损伤的患者中，我们同时测量了人脑和皮下脂肪组织中未结合的细胞外液（ECF）浓度，并将其与动脉血中的吗啡水平进行了比较。该报告显示，与未受伤的脑组织相比，大脑创伤部位附近的吗啡水平有所增加。吗啡在未受伤和受伤脑组织中的半衰期分别为 178 分钟和 169 分钟，两者相当，但比血液（64 分钟）和脂肪组织（63 分钟）更长。这表明吗啡在脑组织中保留的时间比从血液浓度-时间曲线中预期的时间要长。这些结果显示了微透析技术在提供有关药物在靠近创伤部位的人脑和宏观完整组织中的药代动力学的新信息方面的潜力。
Intracerebral microdialysis was utilised to obtain information regarding how morphine is transported across the blood-brain barrier (BBB). In a patient with a severe brain injury, we measured simultaneously unbound extracellular fluid (ECF) concentrations of morphine in human brain and in subcutaneous fat tissue, which were compared to morphine levels in arterial blood. This report shows an increase in morphine levels near the trauma site in the brain compared to uninjured brain tissue. The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, respectively, were comparable but were longer than in blood (64 min) and adipose tissue (63 min). This indicates that morphine is retained in brain tissue for a longer time than what could be expected from the blood concentration-time profile. These results show the potential of the microdialysis technique in providing new information regarding the pharmacokinetics of drug in the human brain close to the trauma site and in macroscopically intact tissue.