Bioorthogonal chemistry for pre-targeted molecular imaging - progress and prospects
Bioorthogonal chemistry for pre-targeted molecular imaging - progress and prospects
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DOI：
10.1039/c3ob40897c
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发表时间：
2013-09-21
影响因子：
3.2
通讯作者：
Spivey, Alan C.
中科院分区：
文献类型：
--
作者：
Carroll, Laurence;Evans, Helen L.;Spivey, Alan C.
这一观点的目的是批判性地回顾目前在纯化学水平和生物系统背景下使用的三种最重要的生物正交反应。这包括治疗分子的合成、大生物分子或抗体的修饰的用途，特别是在“预靶向”领域的令人兴奋的用途，用于可能的治疗和成像技术。我们将比较每种反应与其他反应的有效性以及它们在生物系统中的有用性，因为每种方法在不同的环境中都比其他方法具有明显的优势。
The aim of this perspective is to critically review the three most prominent bioorthogonal reactions that are used presently, on both a purely chemical level and in the context of biological systems. This includes the uses both for synthesis of therapeutic molecules, modification of large biomolecules or antibodies, and in particular, the exciting use in the field of 'pre-targeting', for both possible treatment and imaging technologies. We will compare the validity of each reaction when compared to others, and their usefulness in biological systems, as each methodology has clear advantages over the others in differing environments.