Effect of pentobarbital anesthesia on rheology and transport of canine tracheal mucus.
Effect of pentobarbital anesthesia on rheology and transport of canine tracheal mucus.
复制标题
戊巴比妥麻醉对犬气管粘液流变学和运输的影响。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
P. Macklem
中科院分区：
文献类型：
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作者：
M. King;L. Engel;P. Macklem
在戊巴比妥麻醉诱导前后，从6只气管切开犬中采集气管粘液样本。粘液的动态力学性能测定的磁性显微流变仪技术。在15个实验中，在1 rad/s的弹性的平均值从麻醉前的67 dyn/cm 2上升到212 dyn/cm 2在诱导后的15-90分钟期间。在同一时间，平均粘度在1弧度/秒上升从24至79 P.的粘液纤毛运输的一些粘液样品进行了测定，通过在体外蛙腭技术。在10次实验中，犬气管粘液的相对转运率由麻醉前蛙腭对照的98%上升到戊巴比妥麻醉时的79%。从上颚转运率与粘液弹性呈负相关，在粘液弹性不变的情况下，从上颚转运率与粘液粘度呈负相关。最后，粘液收集率在麻醉期间减少了约8倍，表明粘液的平均深度减少。
Tracheal mucus samples were collected from six tracheostomized dogs before and after induction of pentobarbital anesthesia. The dynamic mechanical properties of the mucus were determined by the magnetic microrheometer technique. In 15 experiments, the mean value of elasticity at 1 rad/s rose from 67 dyn/cm2 before anesthesia to 212 dyn/cm2 in the period 15-90 min after induction. At the same time, mean viscosity at 1 rad/s rose from 24 to 79 P. The mucociliary transportability of some of the mucus samples was assayed by means of in vitro frog palate technique. In 10 experiments, the relative transport rate for dog tracheal mucus went from 98% of frog palate control befor anesthesia to 79% during pentobarbital anesthesia. A negative relationship between from palate transport rate and mucus elasticity was found. A negative correlation between transport and mucus viscosity at constant elasticity was also discovered. Finally, the mucus collection rate was reduced by a factor of about 8 during anesthesia, suggesting a reduction in the average depth of mucus.