Anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm: A case report.
Anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm: A case report.
复制标题
DOI：
10.3892/mco.2015.671
复制
发表时间：
2016-01
影响因子：
1.2
通讯作者：
Uchiyama K
中科院分区：
文献类型：
--
作者：
Fujii K;Nitta T;Kawasaki H;Kataoka J;Tominaga T;Inoue Y;Kadota E;Ishibashi T;Uchiyama K
我们在此报告一例发生于导管内乳头状黏液性肿瘤的间变性胰腺癌。一位68岁的日本女性因疲劳住进了我们的医院。计算机断层扫描显示胰头有一个不规则肿块，在弥散加权磁共振成像上显示为高信号。因此，患者被诊断为胰腺癌，并接受了胰腺十二指肠切除术。组织病理学检查显示胰管内乳头增生性改变，累及胰头的主管和支管。根据免疫组织化学结果，导管内病变被诊断为IPMN。病理诊断为间变性胰腺巨细胞癌(ACP)，IPMN向ACP脱分化的病灶位于IPMN周围。术后18个月，患者保持无病状态。
We herein report a case of anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm (IPMN). A 68-year-old Japanese woman was admitted to our hospital complaining of fatigue. Computed tomography revealed an irregular mass in the pancreatic head, which displayed high-signal intensity on diffusion-weighted magnetic resonance imaging. Accordingly, the patient was diagnosed with pancreatic cancer and underwent pancreaticoduodenectomy. The histopathological findings revealed intraductal papillary proliferative changes involving the main and branch ducts of the pancreatic head. Based on the immunohistochemistry results, the intraductal lesion was diagnosed as IPMN. The pathological diagnosis for the invasive carcinoma was anaplastic giant-cell carcinoma of the pancreas (ACP), and the focus of IPMN dedifferentiation to ACP was found to be located at the periphery of the IPMN. At 18 months postoperatively, the patient remains disease-free.