Antibodies and Antimatter: The Resurgence of Immuno-PET
Antibodies and Antimatter: The Resurgence of Immuno-PET
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DOI：
10.2967/jnumed.108.056887
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发表时间：
2009-01-01
影响因子：
9.3
通讯作者：
Wu, Anna M.
中科院分区：
文献类型：
--
作者：
Wu, Anna M.
人类基因组的完成，再加上蛋白质组学和系统生物学的并行重大研究工作，导致了关于单个基因和蛋白质在正常生理过程中的作用及其在疾病中的破坏的大量信息。在实践中，随着特定分子标志物的识别和验证，这些信息为越来越有针对性的治疗打开了大门。正在进行的从经验医学到分子医学的转变产生了对相应的分子诊断的需求，包括非侵入性分子成像。关于定义正常生物过程和疾病的关键生物标记物的知识与蛋白质和成像技术的融合使现在是重新探讨抗体和PET或免疫PET组合的好时机。
The completion of the human genome, coupled with parallel major research efforts in proteomics and systems biology, has led to a flood of information on the roles of individual genes and proteins in normal physiologic processes and their disruptions in disease. In practical terms, this information has opened the door to increasingly targeted therapies as specific molecular markers are identified and validated. The ongoing transition from empiric to molecular medicine has engendered a need for corresponding molecular diagnostics, including noninvasive molecular imaging. Convergence of knowledge regarding key biomarkers that define normal biologic processes and disease with protein and imaging technology makes this an opportune time to revisit the combination of antibodies and PET, or immuno-PET.