Is there a role for autoimmunity in immune protection against malaria?
Is there a role for autoimmunity in immune protection against malaria?
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DOI：
10.1590/s0074-02762000000200011
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发表时间：
2000-03-01
影响因子：
2.8
通讯作者：
Daniel-Ribeiro, CT
中科院分区：
文献类型：
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作者：
Daniel-Ribeiro, CT
对疟疾保护性免疫涉及的机制以及获得这种免疫的方式仍有许多了解，这可能是尽管取得了如此大的进展，但仍无法开发出能够诱导寄生虫特异性抗体(Ab)和/或T细胞的抗疟疾疫苗的原因。80年代初，人们认为，如果不同时引发针对红细胞的自身免疫(AI)反应，即使以诱导AI病理为代价，也不可能诱导对恶性疟原虫血液期形式的有效保护。尽管描述了相互关系，即疟疾对人工智能疾病发展的保护作用--自1970年以来--但没有努力核实人工智能应对措施是否可能参与预防疟疾。有鉴于此，并鉴于在自身免疫中获得的知识和所谓的“天然”(与病理无关)自身抗体的存在，我们建议检验这样一种假设，即人工免疫反应(不一定限于自体红细胞抗原)参与对疟疾的免疫保护是可能的，甚至是必要的。
Much remains to be known about the mechanisms involved in protective immunity against malaria and the way it is acquired This is probably the reason why in spite of so much progress, it has not yet been possible to develop an anti-malaria vaccine able to induce parasite specific antibodies (Ab) and/or T-cells. It has been considered in the early 80s that the induction of efficient protection against the blood stage forms of Plasmodium falciparum would not be possible without simultaneously eliciting an autoimmune, (AI) response against erythrocytes, even at the price of inducing an AI pathology. Despite the description of the reciprocal relationship, i.e. the protective effect of malaria on the development of AI diseases - demonstrated since 1970 - no effort has been made to verify the possible involvement of the AI response in protection against malaria. With this end in view - and in the light of the knowledge acquired in autoimmunity and the existence of the so called "natural'' (not associated with pathology) autoantibodies - we propose to examine the hypothesis that the participation of the AI response (not necessarily, restricted to autologous erythrocyte antigens) in the immune protection against malaria is possible or even necessary.