Photon-cell interactive monte carlo (pciMC) model to describe both intracellular and extracellular optical pathways for biconcave red blood cells: phase function and albedo
Photon-cell interactive monte carlo (pciMC) model to describe both intracellular and extracellular optical pathways for biconcave red blood cells: phase function and albedo
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DOI：
10.1117/12.841780
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
D. Sakota;S. Takatani
中科院分区：
文献类型：
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作者：
D. Sakota;S. Takatani
建立了一个光子细胞相互作用蒙特卡罗（“pciMC”）模型来量化具有有限体积和细胞内血红蛋白的三维双凹红细胞（RBC）模型中的细胞内光学传播。红细胞相对于入射光子的方向是随机的，允许在细胞外或细胞内传播，这取决于入射点和角度，光子在等离子体细胞界面上的传播由斯涅尔定律和菲涅尔定律决定。在本研究中，利用pciMC与heney - greenstein相函数比较了光子通过单个红细胞的传播。吸收依赖的细胞内光程长度进行了评估，比较Mie理论。两种结果吻合良好。pciMC可以通过量化细胞外和细胞内的光传播来促进血液和组织的光谱学。
A photon-cell interactive Monte Carlo ("pciMC") model was developed to quantify the intracellular optical propagation in a 3-dimensional biconcave red blood cell (RBC) model having a finite volume and intracellular hemoglobin. The orientation of RBCs with respect to the incident photons was randomized to allow either extra- or intra-cellular propagation depending on the incident point and angles where the photon propagation at the plasma-cell interface was determined by the Snell's law and Fresnell's law. In this study, the photon propagation through single RBC using the pciMC was compared against the Henyey-Greenstein phase function. The absorption dependent intracellular optical path length was evaluated in comparison to Mie theory. Both results showed good agreement. The pciMC can contribute to photo-spectroscopy of blood and tissues by quantifying both extra- and intra-cellular optical propagation.