BODY-FAT MASS, BODY-FAT DISTRIBUTION, AND PUBERTAL DEVELOPMENT - A LONGITUDINAL-STUDY OF PHYSICAL AND HORMONAL SEXUAL-MATURATION OF GIRLS
BODY-FAT MASS, BODY-FAT DISTRIBUTION, AND PUBERTAL DEVELOPMENT - A LONGITUDINAL-STUDY OF PHYSICAL AND HORMONAL SEXUAL-MATURATION OF GIRLS
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DOI：
10.1210/jc.75.2.442
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发表时间：
1992-08-01
影响因子：
5.8
通讯作者：
ERICH, WBM
中科院分区：
文献类型：
--
作者：
DERIDDER, CM;THIJSSEN, JHH;ERICH, WBM
研究了女孩在青春期各阶段的进展速度与身体脂肪量和身体脂肪分布的关系及其与荷尔蒙分布的关系。68名女生参加了一项为期3年的纵向研究。这些女孩被分成了皮褶厚度和腰臀比增加的亚组。他们还根据坦纳的乳房发育分类（M2和M3）进行分组。M2时的年龄与月经初潮年龄仅呈轻微相关，但M2时的年龄以及从该年龄到月经初潮的时间间隔呈负相关。青春期开始时的年龄与体脂量或分布无关。青春期M3后的青春期发育率与体脂量呈负相关。M2时的年龄仅与雌酮（El）相关，而青春期发育率与青春期开始时较高的FSH、El、雌二醇（E2）、E2中未与性激素结合球蛋白结合的部分（非性激素结合球蛋白结合E2）和雄烯二酮血浆水平相关。在青春期开始时，体脂分布，而不是体脂量与总的和非性激素结合球蛋白结合的血浆E2和睾酮水平有关。女性青春期早期体脂分布的变化主要与腰围有关。我们没有发现身体脂肪量或身体脂肪分布触发青春期开始的证据。体脂分布与青春期早期内分泌活动有关。身体脂肪量呈负相关的青春期发展对初潮的速度，但没有明确的迹象内分泌相关的过程是found. We得出结论，青春期和初潮的发病是不平行的青春期事件，青春期早期血浆E1，E2和雄烯二酮水平是预测青春期发展对初潮的速度。我们建议，控制青春期的开始和成熟的下丘脑-垂体性腺轴，负反馈控制方面，至少部分独立。平均而言，这导致青春期开始较晚的女孩的青春期成熟“追赶”。
The rate at which girls progress through the stages of puberty in relation to body fat mass and body fat distribution and its relation to their hormonal profiles was studied. Sixty-eight schoolgirls participated in a longitudinal study during 3 yr. The girls were divided into subgroups with increasing skinfold thicknesses and waist-hip ratio. They were also grouped depending on Tanner's breast development classification (M2 and M3). The age at M2 was only marginally correlated with the menarcheal age, but the age at M2 and the time interval from that age to menarche was negatively correlated. Age at the onset of puberty was not related to body fat mass or distribution. The rate of pubertal development after pubertal stage M3 was negatively related to the body fat mass. Age at M2 was only correlated with estrone (El), while the rate of pubertal development was associated with higher FSH, El, estradiol (E2), the fraction of E2 that was not bound to sex-hormone-binding globulin (non-sex-hormone-binding globulin bound E2) and androstenedione plasma levels at the onset of puberty. Body fat distribution, rather than body fat mass was related to the total and the non-sex-hormone-binding globulin bound plasma levels of E2 and testosterone at the onset of puberty. Changes in body fat distribution in early female puberty were chiefly related to the waist circumferences. We found no evidence that body fat mass or body fat distribution triggers the onset of puberty. Body fat distribution was related to early pubertal endocrine activity. Body fat mass was negatively related to the rate of pubertal development toward menarche, but no clear indications for an endocrine-related process is found. We conclude that onset of puberty and menarche are not parallel pubertal events, and that early pubertal plasma El, E2 and androstenedione levels are predictors for the rate of pubertal development toward menarche. We propose that the control of the onset of puberty and maturation of the hypothalamic-pituitary gonadal axis, with regard to negative feedback control, are at least partially independent. This induces on the average a "catch up" pubertal maturation in girls with a late onset of puberty.