Heterogeneous Copper-Catalysed Cascade Reactions of 2-Bromobenzamides with β-Keto Esters Leading to Isoquinolin-1(2H)-One Derivatives
Heterogeneous Copper-Catalysed Cascade Reactions of 2-Bromobenzamides with β-Keto Esters Leading to Isoquinolin-1(2H)-One Derivatives
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DOI：
10.3184/174751914x14117512932816
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发表时间：
2014-10
影响因子：
1.4
通讯作者：
Hong Zhao;Yi-Chou Wu;Ting Wei;Mingzhong Cai
中科院分区：
文献类型：
--
作者：
Hong Zhao;Yi-Chou Wu;Ting Wei;Mingzhong Cai
以Cs2 CO 3为碱，MCM-41固定的双齿含氮铜配合物[MCM-41-2N-CuI]为催化剂，在二氧六环中，于80 °C实现了铜催化的2-溴苯甲酰胺与β-酮酯的非均相级联反应，以中等至良好的产率得到了各种异喹啉-1（2 H）-酮衍生物。这种多相铜催化剂可以通过简单的过滤回收，重复使用10次而没有明显的活性损失。
The heterogeneous copper-catalysed cascade reaction of 2-bromobenzamides with β-keto esters was achieved in dioxane at 80 °C in the presence of the MCM-41-immobilised bidentate nitrogen copper(I) complex [MCM-41-2N-CuI] with Cs2CO3 as base, affording a variety of isoquinolin-1(2H)-one derivatives in moderate to good yields. This heterogeneous copper catalyst can be recovered by a simple filtration and reused 10 times without significant loss of activity.