The effect of hyperglycemia on the tumor response to irradiation given alone or in combination with hyperthermia.
The effect of hyperglycemia on the tumor response to irradiation given alone or in combination with hyperthermia.
复制标题
高血糖对肿瘤对单独照射或与热疗联合照射的反应的影响。
DOI：
10.2307/3576934
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发表时间：
1987
影响因子：
3.4
通讯作者：
P. Okunieff
中科院分区：
文献类型：
--
作者：
M. Urano;T. Todoroki;J. Kahn;P. Okunieff
研究了高血糖（血糖水平升高）对小鼠肿瘤对单独给予或与热疗组合给予的辐射的反应的影响。肿瘤是自发性C3 H/Sed小鼠纤维肉瘤FSa-II的早期同系移植物。将单细胞悬液移植到足部，当每个肿瘤达到平均直径7 mm时给予照射。照射后，研究肿瘤生长达到1000 mm 3的时间，并拟合肿瘤生长时间与辐射剂量之间的剂量-反应曲线。葡萄糖的预给药增加了缺氧和慢性缺氧细胞部分的大小，而不改变剂量-反应曲线的斜率，其中慢性缺氧细胞部分被确定为在高压氧条件下未被氧化的细胞部分。辐射前给予热疗增强了肿瘤对辐射的反应，但同时增加了缺氧和慢性缺氧细胞部分的大小。在照射后给予热疗后观察到类似的结果。当在43.5摄氏度的高温照射前24小时，缺氧细胞部分的大小随着治疗时间的增加而增加，而观察到慢性缺氧细胞部分的大幅减少。在热疗前60分钟给予葡萄糖进一步增加了缺氧细胞部分的大小。解释为什么葡萄糖管理增加缺氧细胞分数的可能机制进行了讨论。
The effect of hyperglycemia (elevated blood glucose level) on the response of a murine tumor to irradiation given alone or in combination with hyperthermia was studied. Tumors were early generation isotransplants of a spontaneous C3H/Sed mouse fibrosarcoma, FSa-II. Single-cell suspensions were transplanted into the foot, and irradiation was given when each tumor reached an average diameter of 7 mm. Following irradiation, the tumor growth time to reach 1000 mm3 was studied and the dose-response curve between the tumor growth time and radiation dose was fitted. Preadministration of glucose increased the size of the hypoxic and chronically hypoxic cell fractions without altering the slope of the dose-response curve where the chronically hypoxic cell fraction is determined as the fraction of cells which were not oxygenated under hyperbaric oxygen conditions. Hyperthermia given prior to irradiation enhanced the tumor response to irradiation, but simultaneously increased the size of the hypoxic and chronically hypoxic cell fractions. Similar results were observed following hyperthermia given after irradiation. When hyperthermia at 43.5 degrees C was given 24 h before irradiation, the size of the hypoxic cell fraction increased with increasing treatment time, while a substantial decrease in the chronically hypoxic cell fraction was observed. Administration of glucose 60 min before hyperthermia further increased the size of the hypoxic cell fraction. Possible mechanisms explaining why glucose administration increases the hypoxic cell fractions are discussed.
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热化疗（环磷酰胺和热疗相结合）伴或不伴高血糖，作为放疗的辅助疗法。
DOI：
10.1016/0360-3016(86)90414-1
发表时间：
1986
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Urano,M;Kahn,J;Kenton,LA
通讯作者：
Kenton,LA
在不同温度下给予或不给予葡萄糖的热化疗（环磷酰胺联合热疗）对小鼠纤维肉瘤的影响。
影响因子：
11.2
作者：
Urano,M;Kim,MS;Kahn,J;Kenton,LA;Li,ML
通讯作者：
Li,ML
高血糖对小鼠正常组织和肿瘤组织热反应的影响。
影响因子：
11.2
作者：
Urano,M;Montoya,V;Booth,A
通讯作者：
Booth,A
热疗治疗小鼠肿瘤中缺氧和长期缺氧细胞分数的变化。
影响因子：
3.4
作者：
Urano,M;Kahn,J
通讯作者：
Kahn,J