Byonic: advanced peptide and protein identification software.
Byonic: advanced peptide and protein identification software.
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DOI：
10.1002/0471250953.bi1320s40
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发表时间：
2012-12
影响因子：
--
通讯作者：
Becker, Christopher
中科院分区：
文献类型：
--
作者：
Bern, Marshall;Kil, Yong J;Becker, Christopher
Byonic™ is the name of a software package for peptide and protein identification by tandem mass spectrometry. This software, which has only recently become commercially available, facilitates a much wider range of search possibilities than previous search software such as SEQUEST and Mascot. Byonic allows the user to define an essentially unlimited number of variable modification types. Byonic also allows the user to set a separate limit on the number of occurrences of each modification type, so that a search may consider only one or two chance modifications such as oxidations and deamidations per peptide, yet allow three or four biological modifications such as phosphorylations, which tend to cluster together. Hence Byonic can search for 10s or even 100s of modification types simultaneously without a prohibitively large combinatorial explosion. Byonic’s Wildcard Search™ allows the user to search for unanticipated or even unknown modifications alongside known modifications. Finally, Byonic’s Glycopeptide Search allows the user to identify glycopeptides without prior knowledge of glycan masses or glycosylation sites.
