LACK OF MHC CLASS-I ANTIGENS AND TUMOR AGGRESSIVENESS OF THE SQUAMOUS-CELL CARCINOMA OF THE LARYNX
LACK OF MHC CLASS-I ANTIGENS AND TUMOR AGGRESSIVENESS OF THE SQUAMOUS-CELL CARCINOMA OF THE LARYNX
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DOI：
10.1038/bjc.1990.437
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发表时间：
1990-12-01
影响因子：
8.8
通讯作者：
GARRIDO, F
中科院分区：
文献类型：
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作者：
ESTEBAN, F;CONCHA, A;GARRIDO, F
一系列的60个原发性喉和下咽肿瘤，24个淋巴结转移和正常组织进行了评估，在冷冻切片的MHC I类抗原的表达，使用单克隆抗体和APAAP技术。我们发现13个肿瘤呈现HLA-ABC的总损失，5个具有HLA-A抗原的选择性损失，1个具有HLA-B抗原的缺失。这些损失与临床和病理参数，如T分期，分化程度，根据Jakobsson和Glanz分级系统的评分和白细胞浸润程度在统计学上相关。我们的研究结果使我们得出以下结论：（a）HLA I类基因丢失见于一组侵袭性更强、预后更差的肿瘤;（B）这些表达改变与转移潜能增加无关。因此，喉肿瘤中HLA分子的缺乏与更大的局部侵袭性有关，I类抗原的丢失似乎构成了一种适应性肿瘤机制，以避免喉内不同的解剖学和免疫学屏障。
A series of 60 primary laryngeal and hypopharyngeal tumours, 24 lymph node metastases and normal tissue were evaluated in frozen sections for the expression of MHC class I antigens, using monoclonal antibodies and the APAAP technique. We found 13 tumours presenting total HLA-ABC loss, five with selective loss of HLA-A antigens and one with absence of HLA-B antigens. These losses were statistically associated with clinical and pathological parameters, such as T stage, degree of differentiation, scores according to the Jakobsson and Glanz grading systems and degree of leukocytic infiltration. Our results lead us to the following conclusions: (a) HLA class I losses were found in a group of tumours showing greater aggressiveness and worse prognosis; (b) these alterations in expression were not associated with an increased metastatic potential. Thus, the absence of HLA molecules in laryngeal tumours is related to greater local aggressiveness, and the loss of class I antigen seems to constitute an adaptive tumour mechanism to avoid the different anatomical and immunological barriers within the larynx.