THE DISPOSITION OF CARBOHYDRATE BETWEEN GLYCOGENESIS, LIPOGENESIS AND OXIDATION IN LIVER DURING THE STARVE-TO-FED TRANSITION
THE DISPOSITION OF CARBOHYDRATE BETWEEN GLYCOGENESIS, LIPOGENESIS AND OXIDATION IN LIVER DURING THE STARVE-TO-FED TRANSITION
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DOI：
10.1042/bj2520325
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发表时间：
1988-06-01
影响因子：
4.1
通讯作者：
SUGDEN, MC
中科院分区：
文献类型：
--
作者：
HOLNESS, MJ;MACLENNAN, PA;SUGDEN, MC
本文比较了4 8h饥饿大鼠的丙酮酸脱氢酶活性、2，6-二磷酸果糖浓度和产脂率、肝脏葡萄糖净流量和肝糖原合成/沉积恢复的时间进程，结果表明，再喂养1h后，糖生成、脂肪生成和净葡萄糖摄取量增加，丙酮酸脱氢酶在3~4h后重新激活，而2，6-二磷酸果糖浓度仅在5~6h后升高，并讨论了这些参数之间的时间关系。
A comparison was made between the time courses of restoration of pyruvate dehydrogenase activities, fructose 2,6-bisphosphate concentrations and lipogenic rates, together with net hepatic glucose flux and glycogen synthesis/deposition in livers of 48 h-starved rats provided with laboratory chow ad libitum for up to 24 h. Increased glycogenesis, lipogenesis and net glucose uptake were observed after 1 h of re-feeding, preceding re-activation of pyruvate dehydrogenase, which occurred after 3-4 h. Increased concentrations of fructose 2,6-bisphosphate were only observed after 5-6 h. The implication of the temporal relationship between these parameters is discussed.