A preliminary study of the release of quaternary ammonium antimicrobial compounds from acrylic bone cement
A preliminary study of the release of quaternary ammonium antimicrobial compounds from acrylic bone cement
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丙烯酸骨水泥中季铵抗菌化合物释放的初步研究
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
J. Nicholson
中科院分区：
文献类型：
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作者：
M. Mathey;V. Surana;M. Edwards;J. Nicholson
研究了季铵盐类化合物苯扎氯铵和十六烷基氯吡啶作为潜在的抗微生物添加剂掺入丙烯酸骨水泥中。使用商用骨水泥Palacos K-40，每种化合物分别以1%和5%的质量添加。水泥凝结时间为9.75 min。当苯扎氯铵（5%）存在时，这一过程没有改变，但在5%十六烷基氯化吡啶的作用下缩短到9.00 min。通过使用氯离子选择电极测定水泥样品中氯离子的释放来估计添加剂的释放。这表明释放发生了，但是一个复杂的过程，而不是遵循简单的扩散动力学。因此，释放过程似乎与骨水泥中硫酸庆大霉素的释放机制相似。结果表明，这些抗微生物化合物可以掺入丙烯酸骨水泥中并以令人满意的方式释放，表明这些化合物具有取代硫酸庆大霉素作为骨科骨水泥有效成分的潜力。
The quaternary ammonium compounds benzalkonium chloride and cetyl pyridinium chloride have been studied as potential anti-microbial additives for incorporation into acrylic bone cement. Using the commercial bone cement Palacos K-40, each compound was added at 1% and 5% by mass. Setting time of the cement was 9.75 min. This did not change when benzalkonium chloride (5%) was present, but was shortened to 9.00 min by 5% cetyl pyridinium chloride. Release of additive was estimated by determining chloride release from set cement specimens using a chloride-ion selective electrode. This showed that release occurred but was a complicated process and did not follow simple diffusion-based kinetics. Release thus appeared to occur by a similar overall mechanism to that of gentamicin sulphate from bone cements. The results show that these anti-microbial compounds can be incorporated into acrylic bone cement and then released in a satisfactory manner and suggest that these compounds have the potential to replace gentamicin sulphate as active ingredients in orthopaedic cements.