Transcranial direct current stimulation and transcranial random noise stimulation over the cerebellum differentially affect the cerebellum and primary motor cortex pathway
Transcranial direct current stimulation and transcranial random noise stimulation over the cerebellum differentially affect the cerebellum and primary motor cortex pathway
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小脑经颅直流电刺激和经颅随机噪声刺激对小脑和初级运动皮层通路的影响不同
DOI：
10.1016/j.jocn.2022.04.003
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发表时间：
2022
影响因子：
2
通讯作者：
Onishi Hideaki
中科院分区：
文献类型：
--
作者：
Kawakami Saki;Inukai Yasuto;Ikarashi Hitomi;Watanabe Hiraku;Miyaguchi Shota;Otsuru Naofumi;Onishi Hideaki
经颅直流电刺激（tDCS）和经颅随机噪声刺激（tRNS）是两种非侵入性调节放置电极下方皮质兴奋性的方法。小脑上的阳极tDCS已被证明可以调节小脑脑抑制（CBI），这是小脑兴奋性的一个指标，但不会改变对侧M1兴奋性。然而，tRNS对小脑的影响尚未研究。因此，本研究的目的是比较tDCS和tRNS在小脑上对CBI和对侧运动诱发电位（MEP）的影响，以及CBI和对侧MEP之间的关系。共有15名健康受试者在不同日期完成了四种条件的经颅电刺激（tES）干预（阳极tDCS_1 mA、阳极tDCS_2 mA、tRNS和假手术）。在20 min tES干预前后使用经颅磁刺激（TMS）测量CBI和MEP。在所有条件下，CBI或对侧MEP在tES前后均无显著差异。相反，tRNS后，CBI和MEP的变化显著相关。在其他三种情况下，没有发现显着的相关性，表明小脑tDCS和tRNS有不同的影响CBI和对侧MEP之间的关系。总之，这些发现表明，小脑tRNS可能调节小脑对侧M1通路。
Transcranial direct current stimulation (tDCS) and transcranial random noise stimulation (tRNS) are two methods of noninvasively modulating cortical excitability below the placed electrode. Anodal tDCS over the cerebellum has been shown to modulate cerebellar brain inhibition (CBI), which is an indication of cerebellar excitability, but does not alter contralateral M1 excitability. However, the effect of tRNS over the cerebellum has not been investigated. The purpose of this study was thus to compare the effects of tDCS and tRNS over the cerebellum on CBI and the contralateral motor evoked potentials (MEPs), as well as on the relationship between CBI and contralateral MEPs. A total of 15 healthy subjects completed four-condition transcranial electrical stimulation (tES) interventions (anodal tDCS_1 mA, anodal tDCS_2 mA, tRNS, and Sham) on separate days. CBI and MEPs were measured using transcranial magnetic stimulation (TMS) before and after the 20 min tES intervention. For all conditions, there were no significant differences before and after tES in CBI or contralateral MEPs. In contrast, following tRNS, changes in CBI and MEPs were significantly correlated. No significant correlations were found in the other three conditions, indicating that cerebellar tDCS and tRNS have distinct effects on the relationship between CBI and contralateral MEPs. Taken together, these findings suggest that cerebellar tRNS may modulate the cerebellar to contralateral M1 pathway.