Uric acid correlates to oxidation and inflammation in opposite directions in women.
Uric acid correlates to oxidation and inflammation in opposite directions in women.
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DOI：
10.3109/1354750x.2015.1068852
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Yang G
中科院分区：
文献类型：
--
作者：
Wu SH;Shu XO;Milne G;Xiang YB;Zhang X;Cai Q;Fazio S;Linton MF;Chen H;Purdue M;Rothman N;Gao YT;Zheng W;Yang G
评估尿酸（UA）水平与一组氧化应激和炎症标志物的相关性。对755名中国妇女的血浆UA水平、氧化应激和炎症标志物进行了沿着测定。血浆UA水平与尿中氧化应激标志物F2-异前列腺素水平呈负相关，与血液中炎症标志物如C-反应蛋白和某些促炎细胞因子（肿瘤坏死因子-α和白细胞介素-6）以及尿中前列腺素E2代谢产物水平呈正相关。血浆UA水平与女性氧化和炎症生物标志物呈相反方向相关。
To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation. Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women. Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine. Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.