Neuropeptides, Peptide Hormones, and Their Receptors of a Tunicate, Ciona intestinalis
Neuropeptides, Peptide Hormones, and Their Receptors of a Tunicate, Ciona intestinalis
复制标题
神经肽、肽激素及其被囊类海鞘的受体
DOI：
10.1007/978-3-030-23459-1_5
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kawada Tsuyoshi
中科院分区：
文献类型：
--
作者：
Satake Honoo;Matsubara Shin;Shiraishi Akira;Yamamoto Tatsuya;Osugi Tomohiro;Sakai Tsubasa;Kawada Tsuyoshi
海鞘作为脊椎动物的近亲，其系统发育的关键位置表明其作为模式生物的潜在适用性，包括神经，神经内分泌和内分泌调节的各种生物事件。迄今为止，已经鉴定了大约40种神经肽和/或肽激素以及几种同源受体。这些肽分为两类：（1）脊椎动物肽的直系同源物，例如胆囊收缩素、GnRH、速激肽、加压素和降钙素，和（2）新家族肽，例如LF肽和YFL/V肽。（Ci-GnRHR）在Ciona特异性谱系中增殖，并在Ci-GnRHR 1和R4之间以及Ci-GnRHR 2和R4之间形成独特的异二聚体，导致第二信使的产生的微调。此外，Cionatachykinin被证明可以调节一种新的蛋白酶相关的卵泡生长途径。这些发现将为探索无脊椎动物后口动物和/或脊索动物进化谱系中保守和多样化的内分泌、神经内分泌和神经系统铺平道路。在这一章中，我们提供了一个概述的主要序列，功能和进化方面的神经肽，肽激素，和它们的受体在C。好吧
The critical phylogenetic position of the ascidian,Ciona intestinalis, as the closest relative of vertebrates, suggested its potential applicability as a model organism in a wide variety of biological events including the nervous, neuroendocrine, and endocrine regulation. To date, approximately 40 neuropeptides and/or peptide hormones and several cognate receptors have been identified. These peptides are categorized into two types: (1) orthologs of vertebrate peptides, such as cholecystokinin, GnRH, tachykinin, vasopressin, and calcitonin, and (2) novel family peptides such as LF peptides and YFL/V peptides.CionaGnRH receptors (Ci-GnRHR) were found to be multiplicated in theCiona-specific lineages and to form unique heterodimers between Ci-GnRHR1 and R4 and between Ci-GnRHR2 and R4, leading to fine-tuning of the generation of second messengers. Furthermore,Cionatachykinin was shown to regulate a novel protease-associated follicle growth pathway. These findings will pave the way for the exploration of both conserved and diversified endocrine, neuroendocrine, and nervous systems in the evolutionary lineage of invertebrate deuterostomes and/or chordates. In this chapter, we provide an overview of primary sequences, functions, and evolutionary aspects of neuropeptides, peptide hormones, and their receptors inC. intestinalis.