THE MULTICENTER AIDS COHORT STUDY - RATIONALE, ORGANIZATION, AND SELECTED CHARACTERISTICS OF THE PARTICIPANTS
THE MULTICENTER AIDS COHORT STUDY - RATIONALE, ORGANIZATION, AND SELECTED CHARACTERISTICS OF THE PARTICIPANTS
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DOI：
10.1093/aje/126.2.310
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发表时间：
1987-08-01
影响因子：
5
通讯作者：
RINALDO, CR
中科院分区：
文献类型：
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作者：
KASLOW, RA;OSTROW, DG;RINALDO, CR
多中心艾滋病队列研究的目的是1)阐明导致获得性免疫缺陷综合征(AIDS)的感染的自然历史，2)确定感染发生的危险因素和临床表现，3)建立生物标本储存库，用于未来的研究。采用了各种招聘技术，包括特别保证保密，以登记参与者。近5,000名男同性恋者自愿参加四个大都市地区的半年一次的面谈、体检和实验室检测。在每个中心的这些男性中，显著的大多数(69%-83%)报告说有50个或更多的终身性伴侣，超过80%的人在过去两年中至少与他们的一些伴侣进行过接受性肛交。在参与者进行初步评估时(1984年4月至1985年4月)，洛杉矶(51%)和芝加哥(43%)男性感染人类免疫缺陷病毒(HIV)的比例高于巴尔的摩/华盛顿特区(31%)和匹兹堡(21%)，这可能是由于这些男性从事高风险行为(例如接受性肛交)的伴侣数量和比例较高。这项全面的艾滋病毒感染纵向调查正在进行后续评估。
The Multicenter AIDS Cohort Study was designed to 1) elucidate the natural history of the infection causing acquired immunodeficiency syndrome (AIDS), 2) identify risk factors for occurrence and clinical expression of the infection, and 3) establish a repository of biologic specimens for future study. A variety of recruitment techniques, including special assurance of confidentiality, were used to enroll participants. Nearly 5,000 homosexual men volunteered for semiannual interview, physical examination, and laboratory testing in four metropolitan [USA] areas. A significant majority of these men in each center (69-83%) reported having 50 or more lifetime sexual partners, and over 80% had engaged in receptive anal intercourse with at least some of their partners in the previous two years. By the time of the participants'' initial evaluation (April 1984-April 1985), infection with the human immunodeficiency virus (HIV) had occurred in higher proportions of men in Los Angeles (51%) and Chicago (43%) than in Baltimore/Washington, DC (31%) and Pittsburgh (21%), presumably as a result of the higher number of partners and proportion with whom these men had engaged in high-risk practices (e.g., receptive anal intercourse). Follow-up evaluations are underway in this comprehensive longitudinal investigation of HIV infection.