Preparation of poly(ethylene glycol)-modified poly(amido amine) dendrimers encapsulating gold nanoparticles and their heat-generating ability
Preparation of poly(ethylene glycol)-modified poly(amido amine) dendrimers encapsulating gold nanoparticles and their heat-generating ability
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DOI：
10.1021/la0700826
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发表时间：
2007-05-08
期刊：
影响因子：
3.9
通讯作者：
Kono, Kenji
中科院分区：
文献类型：
--
作者：
Haba, Yasuhiro;Kojima, Chie;Kono, Kenji
将 HAuCl4 负载到在所有链端具有聚乙二醇 (PEG) 接枝的聚（酰胺基胺）G4 树枝状聚合物中，然后用 NaBH4 还原，产生了封装约 100 微米金纳米粒子（Au NP）的 PEG 修饰树枝状聚合物。 2纳米直径。树枝状聚合物中的金纳米颗粒在水溶液中稳定，即使在冷冻干燥后也很容易溶解。尽管粒径较小，但树枝状聚合物中金纳米粒子的生热能力与广泛使用的金纳米粒子相当。可见光照射下直径为11 nm。观察到的优异的胶体稳定性、高生热能力及其生物相容性表面证实，封装 Au NP 的 PEG 修饰树枝状大分子是光热治疗和成像的有前途的工具。
Loading of HAuCl4 in poly(amido amine) G4 dendrimers having poly(ethylene glycol) (PEG) grafts at all chain ends and subsequent reduction with NaBH4 yielded PEG-modified dendrimers encapsulating gold nanoparticles (Au NPs) of ca. 2 nm diameter. The Au NPs held in the dendrimers were stable in aqueous solutions and dissolved readily, even after freeze-drying. Despite their small particle size, the heat-generating ability of Au NPs held in the dendrimer was comparable to that of widely used Au NPs with ca. 11 nm diameter under visible light irradiation. The observed excellent colloidal stability, high heat-generating ability and their biocompatible surface confirm that the PEG-modified dendrimers encapsulating Au NPs are a promising tool for photothermal therapy and imaging.