Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men - Prospective results from the Quebec Cardiovascular Study
Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men - Prospective results from the Quebec Cardiovascular Study
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DOI：
10.1161/01.cir.95.1.69
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发表时间：
1997-01-07
期刊：
影响因子：
37.8
通讯作者：
Despres, JP
中科院分区：
文献类型：
--
作者：
Lamarche, B;Tchernof, A;Despres, JP
背景：病例对照研究报道，缺血性心脏病（IHD）患者比健康对照组有更高比例的小而致密的LDL颗粒。在何种程度上归因于小LDL颗粒的风险可能是独立的血浆脂蛋白-脂质浓度的伴随变化仍有待明确确定，但是，特别是通过前瞻性study.Methods和结果的基线特征，获得在2103名男子最初免费IHD，其中114开发IHD在5年的随访期间。这114例患者与健康对照组的年龄，体重指数，吸烟习惯和饮酒量相匹配。采用全血浆非变性梯度凝胶电泳法，对103对病例对照组的低密度脂蛋白峰粒径（PPD）进行了后验测定。病例对照状态的条件logistic回归分析显示，对照LDL-PPD分布的第一个三分位数（LDL-PPD小于或等于25.64 nm）的男性与第三个三分位数（LDL-PPD>26.05 nm）的男性相比，MD风险增加3.6倍（95% CI，1.5 - 8.8）。LDL胆固醇，甘油三酯，HDL胆固醇，和载脂蛋白B浓度的伴随变化的统计调整几乎没有影响之间的关系小LDL颗粒和IHD. Conclusions的风险，这些结果代表了第一个前瞻性的证据表明，小，致密的LDL颗粒的存在可能与随后在男性发展IHD的风险增加。结果还表明，归因于小LDL颗粒的风险可能部分独立于血浆脂蛋白-脂质浓度的伴随变化。
Background Case-control studies have reported that patients with ischemic heart disease (IHD) have a higher proportion of small, dense LDL particles than do healthy control subjects. The extent to which the risk attributed to small LDL particles may be independent of concomitant variations in plasma lipoprotein-lipid concentrations remains to be clearly determined, however, particularly through prospective studies.Methods and Results Baseline characteristics were obtained in 2103 men initially free of IHD, among whom 114 developed IHD during a 5-year follow-up period. These 114 case patients were matched with healthy control subjects for age, body mass index, smoking habits, and alcohol intake. LDL peak particle diameter (PPD) was measured a posteriori in 103 case-control pairs by nondenaturing gradient gel electrophoresis of whole plasma. Conditional logistic regression analysis of the case-control status revealed that men in the first tertile of the control LDL-PPD distribution (LDL-PPD less than or equal to 25.64 nm) had a 3.6-fold increase in the risk of MD (95% CI, 1.5 to 8.8) compared with those in the third tertile (LDL-PPD>26.05 nm). statistical adjustment for concomitant variations in LDL cholesterol, triglycerides, HDL cholesterol, and apolipoprotein B concentrations had virtually no impact on the relationship between small LDL particles and the risk of IHD.Conclusions These results represent the first prospective evidence suggesting that the presence of small, dense LDL particles may be associated with an increased risk of subsequently developing IHD in men. Results also suggest that the risk attributed to small LDL particles may be partly independent of the concomitant variation in plasma lipoprotein-lipid concentrations.