Patient- and proxy-reported quality of life in advanced dementia with Lewy bodies.
Patient- and proxy-reported quality of life in advanced dementia with Lewy bodies.
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患者和代理报告的路易体晚期痴呆患者的生活质量。
DOI：
10.1002/alz.13745
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Li,Zhigang
中科院分区：
文献类型：
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作者：
Armstrong,MelissaJ;LaBarre,Brian;Sovich,Kaitlin;Maixner,SusanM;Paulson,HenryL;Manning,Carol;Fields,JulieA;Lunde,Angela;Forsberg,Leah;Boeve,BradleyF;Galvin,JamesE;Taylor,AngelaS;Li,Zhigang
IntroductionLittle是已知的关于生活质量（QoL）在路易体痴呆症（DLB），特别是在先进的stages.METHODSdyads的个人与中度先进的DLB和他们的主要照顾者被招募专业诊所，宣传组织和研究登记处。该研究收集了人口统计学资料、疾病相关指标和患者/护理人员经验指标。阿尔茨海默病生活质量（QoL-AD）由DLB患者和护理人员（代理人）在61对中完成; 85对中只有代理人完成的QoL-AD。患者和代理人报告的评分中度相关（r= 0.57，P < 0.0001）。患者报告的较差QoL与日间嗜睡、自主症状负担和行为症状相关。代理评级与痴呆的严重程度、日间嗜睡、行为症状、日常生活活动的依赖性和护理人员经验测量相关。建议在晚期DLB中应单独评估患者和代理报告的生活质量（QoL）。与QoL相关的一些症状有可用的治疗选择。需要研究最佳改善DLB生活质量的策略。重点患者和代理生活质量（QoL）评分在路易体晚期痴呆中具有中度相关性。日间嗜睡影响患者和代理报告的QoL。行为症状影响患者和代理报告的QoL。自主神经症状负担影响患者报告的QoL。痴呆严重程度，依赖性和护理人员经验影响代理评分。
INTRODUCTIONLittle is known regarding quality of life (QoL) in dementia with Lewy bodies (DLB), particularly in advanced stages.METHODSDyads of individuals with moderate–advanced DLB and their primary caregivers were recruited from specialty clinics, advocacy organizations, and research registries. The study collected demographics, disease‐related measures, and measures of patient/caregiver experiences.RESULTSThe Quality of Life in Alzheimer's Disease (QoL‐AD) was completed by the person with DLB and the caregiver (proxy) in 61 dyads; 85 dyads had only a proxy‐completed QoL‐AD. Patient‐ and proxy‐reported scores were moderately correlated (r= 0.57,P< 0.0001). Worse patient‐reported QoL correlated with daytime sleepiness, autonomic symptom burden, and behavioral symptoms. Proxy ratings correlated with dementia severity, daytime sleepiness, behavioral symptoms, dependence in activities of daily living, and caregiver experience measures.DISCUSSIONPatient‐ and proxy‐reported quality of life (QoL) should be assessed separately in advanced DLB. Some symptoms associated with QoL have available therapeutic options. Research is needed regarding strategies to optimally improve QoL in DLB.HighlightsPatient and proxy quality of life (QoL) ratings had moderate correlation in advanced dementia with Lewy bodies.Daytime sleepiness affected patient‐ and proxy‐reported QoL.Behavioral symptoms affected patient‐ and proxy‐reported QoL.Autonomic symptom burden affected patient‐reported QoL.Dementia severity, dependence, and caregiver experiences affected proxy ratings.