Usefulness of anti-oxidized LDL antibody determination for assessment of clinical control in patients with heart failure
Usefulness of anti-oxidized LDL antibody determination for assessment of clinical control in patients with heart failure
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DOI：
10.1016/j.ejheart.2005.04.015
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发表时间：
2006-01-01
影响因子：
18.2
通讯作者：
Keren, G
中科院分区：
文献类型：
--
作者：
George, J;Wexler, D;Keren, G
背景：氧化应激可能在心力衰竭的发病机制中发挥作用，这可能对治疗策略有潜在的影响。然而，氧化应激的测量结果容易出现令人困惑的不准确。氧化型低密度脂蛋白的免疫球蛋白抗体反映了长时间接触脂蛋白的情况，因此可能反映了长时间的氧化应激。因此，我们验证了这样的假设，即抗oxLDL抗体与心力衰竭(HF)的控制相关，这表现为心脏功能不全的住院治疗。方法：连续102名在HF门诊就诊的收缩或舒张期HF患者，通过评估氧化应激标志物指数确定前一年的住院情况来评估临床控制的质量。结果：大多数患者(平均年龄71.5岁)存在收缩性心衰，平均NYHA功能分级为2.7级，平均左心室射血分数为39.7%。抗oxLDL抗体，而不是前BNP抗体，与NYHA平均评分(从血液检测前一年所有诊所就诊的平均得分)以及血液检测前一年的住院人数显著相关。入院患者的平均抗oxLDL抗体水平是非住院患者的3.4倍。结论：抗oxLDL抗体水平与心衰的严重程度有关。(C)2005年欧洲心脏病学会。爱思唯尔出版公司(Elsevier B.V.)
Background: It has been suggested that oxidative stress may play a role in the pathogenesis of heart failure, this may have potential implications for therapeutic strategies. However, measures of oxidative stress are subject to confounding inaccuracies. IgG antibodies to oxidized LDL reflect exposure to the lipoprotein over an extended period and may thus mirror oxidative stress over a prolonged time frame. Therefore, we tested the hypothesis that anti-oxLDL antibodies correlate with the control of heart failure (HF), as manifested by hospital admissions for cardiac dysfunction.Methods: One hundred and two consecutive patients attending the HF clinic with either systolic or diastolic HF were enrolled and the quality of clinical control was evaluated by assessing hospital admissions over the year prior to index determination of the oxidative stress marker. Antibodies to oxLDL were determined by ELISA and pro-BNP levels were also measured.Results: Most patients (mean age 71.5 years) had systolic HF; mean NYHA functional class was 2.7 and mean left ventricular ejection fraction was 39.7%. Anti-oxLDL antibodies, but not pro-BNP, correlated significantly with mean NYHA score (averaged from all clinic visits in the year prior to blood testing), and with hospital admissions over the year prior to blood testing. Mean IgG anti-oxLDL antibody levels in patients with hospital admissions were 3.4 times higher than those in subjects not hospitalized over the previous year.Conclusion: IgG anti-oxLDL antibody levels correlate with the severity of HF. (c) 2005 European Society of Cardiology. Published by Elsevier B.V.