Identification of immunogenic consensus T-cell epitopes in globally distributed influenza-A H1N1 neuraminidase
Identification of immunogenic consensus T-cell epitopes in globally distributed influenza-A H1N1 neuraminidase
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DOI：
10.1016/j.meegid.2010.10.013
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发表时间：
2011-03-01
影响因子：
3.2
通讯作者：
Gupta, Shailendra K.
中科院分区：
文献类型：
--
作者：
Gupta, Shishir K.;Srivastava, Mugdha;Gupta, Shailendra K.
抗原漂移是猪流感病毒响应宿主免疫系统而发生连续和渐进变化的能力。这些变化要求每年更新流感疫苗，以确保包含最新毒株的抗原。识别那些刺激 T 细胞反应的肽（称为 T 细胞表位）对于成功开发疫苗至关重要。在这项研究中，预测了全球分布的 H1N1 病毒株神经氨酸酶的高度保守和特异性表位，以便这些潜在的候选疫苗可能会随着抗原漂移而逃脱。总共九个针对 MHC I 类的新 CD8(+) T 细胞表位和八个针对 MHC II 类等位基因的新 CD4(+) T 细胞表位被提议作为基于新表位的候选疫苗。此外，表位 FSYKYGNCV 被鉴定为高度保守、具有免疫原性和潜在的候选疫苗，能够产生 CD8(+) 和 CD4(+) 反应。 (c) 2010 Elsevier B.V. 保留所有权利。
Antigenic drift is the ability of the swine influenza virus to undergo continuous and progressive changes in response to the host immune system. These changes dictate influenza vaccine updates annually to ensure inclusion of antigens of the most current strains. The identification of those peptides that stimulate T-cell responses, termed T-cell epitopes, is essential for the development of successful vaccines. In this study, the highly conserved and specific epitopes from neuraminidase of globally distributed H1N1 strains were predicted so that these potential vaccine candidates may escape with antigenic drift. A total of nine novel CD8(+) T-cell epitopes for MHC class-I and eight novel CD4(+) T-cell epitopes for MHC class-II alleles were proposed as novel epitope based vaccine candidates. Additionally, the epitope FSYKYGNCV was identified as a highly conserved, immunogenic and potential vaccine candidate, capable for generating both CD8(+) and CD4(+) responses. (c) 2010 Elsevier B.V. All rights reserved.