Autism spectrum disorder and celiac disease: no evidence for a link
Autism spectrum disorder and celiac disease: no evidence for a link
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DOI：
10.1590/s0004-282x2012000100007
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发表时间：
2012-01-01
影响因子：
1.4
通讯作者：
Pratesi, Riccardo
中科院分区：
文献类型：
--
作者：
Batista, Icaro Camargo;Gandolfi, Lenora;Pratesi, Riccardo
目的：探讨乳糜泻（CD）和/或谷蛋白敏感性（GS）与孤独症谱系障碍（ASD）的关系。研究方法：在一组ASD儿童和青少年中确定CD的发生率，相反，在一组活检证实的乳糜泻患者中评估ASD的发生率。为了检测GS的可能存在，对ASD患者的抗麦胶蛋白抗体水平进行了评估，并与一组非乳糜泻儿童的水平进行了比较。结果：ASD患者CD或GS的患病率并不高于来自同一地理区域的人群。同样，ASD的患病率并不高于一组活检证实的CD患者。结论：CD或GS与ASD之间无统计学显著相关性。因此，目前对所有ASD患者进行CD或GS的常规筛查既不合理也不具有成本效益。
Objective: To evaluate the possible association between celiac disease (CD) and/or gluten sensitivity (GS) and autism spectrum disorder (ASD). Methods: Occurrences of CD were determined in a group of children and adolescents affected by ASD and, conversely, occurrences of ASD were assessed in a group of biopsy-proven celiac patients. To detect the possible existence of GS, the levels of antigliadin antibodies in ASD patients were assessed and compared with the levels in a group of non-celiac children. Results: The prevalence of CD or GS in ASD patients was not greater than in groups originating from the same geographical area. Similarly the prevalence of ASD was not greater than in a group of biopsy-proven CD patients. Conclusion: No statistically demonstrable association was found between CD or GS and ASD. Consequently, routine screening for CD or GS in all patients with ASD is, at this moment, neither justified nor cost-effective.