EVIDENCE THAT OPIATE ADDICTION IS IN PART AN IMMUNE-RESPONSE - DESTRUCTION OF THE IMMUNE-SYSTEM BY IRRADIATION-ALTERED OPIATE WITHDRAWAL
EVIDENCE THAT OPIATE ADDICTION IS IN PART AN IMMUNE-RESPONSE - DESTRUCTION OF THE IMMUNE-SYSTEM BY IRRADIATION-ALTERED OPIATE WITHDRAWAL
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DOI：
10.1016/0028-3908(86)90003-1
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发表时间：
1986-08-01
影响因子：
4.7
通讯作者：
PELLIS, NR
中科院分区：
文献类型：
--
作者：
DAFNY, N;PELLIS, NR
进行实验以确定是否可以通过破坏免疫系统来改变对阿片类药物的身体依赖性（CNS现象）。通过纳洛酮诱导的戒断评估，在吗啡长期治疗之前或之后进行照射可显著降低阿片类药物戒断综合征。这项研究支持阿片类药物成瘾与中枢神经系统（CNS）和免疫系统之间的相互作用有关的主张。
Experiments were performed to determine whether physical dependence on opiates (CNS phenomena) can be altered by destruction of the immune system. Irradiation, prior to or after chronic treatment with morphine significantly reduced the opiate-withdrawal syndrome as assessed by naloxone-induced abstinence. This study supports the proposition that addiction to opiates is related, at least in part, to interaction between the central nervous system (CNS) and the immune system.