An Overview of Pharmacologic Management of Chronic Pain
An Overview of Pharmacologic Management of Chronic Pain
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DOI：
10.1016/j.mcna.2015.08.006
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发表时间：
2016-01-01
影响因子：
5.9
通讯作者：
Wallace, Mark S.
中科院分区：
文献类型：
--
作者：
Beal, Benjamin R.;Wallace, Mark S.
慢性疼痛患者的管理可能具有挑战性，历史上供应商一直依赖阿片类药物来治疗疼痛。最近的研究对非癌症人群中长期阿片类药物治疗的安全性和有效性提出了质疑。有大量文献支持使用非甾体抗炎药、抗抑郁药、抗惊厥药、外用药、大麻素和肉毒杆菌毒素与阿片类药物联合或代替阿片类药物。鞘内给药系统可以将这些药物中的一些直接递送到它们的主要作用部位，同时最小化全身给药所见的副作用。
Patients with chronic pain can be challenging to manage and historically providers have relied on opiates to treat pain. Recent studies have brought into question the safety and efficacy of chronic opiate therapy in the non-cancer population. There is a vast amount of literature to support the use of nonsteroidal anti-inflammatory medications, antidepressants, anticonvulsants, topical agents, cannabinoids, and botulinum toxin either in conjunction with or in lieu of opioids. Intrathecal drug delivery systems can deliver some of these medications directly to their primary site of action while minimizing the side effects seen with systemic administration.