The tissue distribution, metabolism, and excretion of octachlorostyrene in the rat.
The tissue distribution, metabolism, and excretion of octachlorostyrene in the rat.
复制标题
八氯苯乙烯在大鼠体内的组织分布、代谢和排泄。
DOI：
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发表时间：
1982
影响因子：
3.9
通讯作者：
A. Viau
中科院分区：
文献类型：
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作者：
I. Chu;D. Villeneuve;V. Secours;F. Benoit;A. Viau
本文研究了~(14)C-八氯苯乙烯(OCS)在大鼠体内的组织分布、代谢和消除。OCS经口给药后在胃肠道吸收，并分布于所有受检组织。脂肪中的浓度最高，其次是肾上腺、皮肤和肺。组织中放射性的衰减遵循一级动力学。大约8%的静脉注射剂量在给药后7天内从粪便中排出，而在尿液中发现的量可以忽略不计。粪便中90%以上的放射性是由未改变的化合物引起的，而五氯苯基二氯乙酸和七氯苯乙烯各占10%。在呼出的空气中检测到少量(1%)的二氧化碳。
The tissue distribution, metabolism, and elimination of 14C-octachlorostyrene (OCS) were studied in the rat. OCS was absorbed in the gastrointestinal tract after oral administration and distributed in all tissues examined. The highest concentrations were found in fat followed by adrenal glands, skin, and lungs. Decay of radioactivity in the tissues followed first-order kinetics. Approximately 8% of an iv dose was excreted in feces during 7 days after administration, while negligible amounts were found in the urine. More than 90% of the radioactivity in feces was due to the unchanged compound, while pentachlorophenyldichloroacetic acid and heptachlorostyrene in equal proportions accounted for the remaining 10%. A small amount (1%) of the dose was detected in the expired air as carbon dioxide.